Literature DB >> 30199269

Correlation of Immune Cells and Cytokines in the Tumor Microenvironment with Elevated Neutrophil-To-Lymphocyte Ratio in Blood: An Analysis of Muscle-Invasive Bladder Cancer.

Yosuke Morizawa1, Makito Miyake1, Keiji Shimada2,3, Shunta Hori1, Yoshihiro Tatsumi1,3, Yasushi Nakai1, Sayuri Onishi1, Nobumichi Tanaka1, Noboru Konishi3, Kiyohide Fujimoto1.   

Abstract

We investigated the relationship between Neutrophil-to-lymphocyte ratio (NLR) and the quantities of neutrophil elastase, CD3, Foxp3, and CD204 in tumor-infiltrating cells and circulating cytokines (IL-2, -6, -8, 17a, and TGF-β) in muscle-invasive bladder cancer. IL-6 and IL-8 levels showed a significant correlation with NLR in blood and Foxp3+ cells around the tumor. After co-culture of peripheral blood cells with bladder cancer cell lines, the induction of regulatory T cell (Treg) was higher in T24 whose IL-6 and IL-8 levels were higher. High NLR correlates with increased IL-6 and IL-8 and Treg expression.

Entities:  

Keywords:  Foxp3; IL-6; IL-8; NLR; muscle-invasive bladder cancer

Mesh：

Substances：

Year:  2018        PMID： 30199269     DOI： 10.1080/07357907.2018.1506800

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  8 in total

1.  High postoperative neutrophil-lymphocyte ratio and low preoperative lymphocyte-monocyte ratio predict poor prognosis in gastric cancer patients receiving gastrectomy with positive lavage cytology: a retrospective cohort study.

Authors:  Sho Sato; Chikara Kunisaki; Masazumi Takahashi; Hirokazu Kubo; Nobuhiro Tsuchiya; Kei Sato; Hiroshi Miyamoto; Yuko Tamura; Hiroki Kondo; Yusaku Tanaka; Kohei Kasahara; Takashi Kosaka; Hirotoshi Akiyama; Yusuke Saigusa; Itaru Endo
Journal:  Langenbecks Arch Surg       Date:  2021-06-17       Impact factor: 3.445

2.  The Significance of Neutrophil-to-Lymphocyte Ratio and Combined Chemoradiotherapy in Patients Undergoing Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer.

Authors:  Chun-Te Wu; Yun-Ching Huang; Wen-Cheng Chen; Miao-Fen Chen
Journal:  Cancer Manag Res       Date:  2020-12-22       Impact factor: 3.989

3.  IL-37 Confers Anti-Tumor Activity by Regulation of m6A Methylation.

Authors:  Xiaofeng Mu; Qi Zhao; Wen Chen; Yuxiang Zhao; Qing Yan; Rui Peng; Jie Zhu; Chunrui Yang; Ketao Lan; Xiaosong Gu; Ye Wang
Journal:  Front Oncol       Date:  2021-01-08       Impact factor: 6.244

4.  Role of Serum Lymphocyte-derived Biomarkers in Nonmetastatic Muscle-invasive Bladder Cancer Patients Treated with Trimodal Therapy.

Authors:  Ronald Kool; Gautier Marcq; Surashri Shinde-Jadhav; José João Mansure; Ramy Saleh; Raghu Rajan; Armen Aprikian; Simon Tanguay; Fabio L Cury; Fadi Brimo; Luis Souhami; Wassim Kassouf
Journal:  Eur Urol Open Sci       Date:  2021-12-23

5.  Development of nomograms related to inflammatory biomarkers to estimate the prognosis of bladder cancer after radical cystectomy.

Authors:  Wentao Zhang; Fuhan Yang; Aimaitiaji Kadier; Yifan Chen; Yang Yu; Junfeng Zhang; Jiang Geng; Yang Yan; Wei Li; Xudong Yao
Journal:  Ann Transl Med       Date:  2021-09

6.  Prognostic Significance of NLR About NETosis and Lymphocytes Perturbations in Localized Renal Cell Carcinoma With Tumor Thrombus.

Authors:  Bingqing Shang; Liping Guo; Rongfang Shen; Chuanzhen Cao; Ruiyang Xie; Weixing Jiang; Li Wen; Xingang Bi; Hongzhe Shi; Shan Zheng; Changling Li; Jianhui Ma; Kaitai Zhang; Lin Feng; Jianzhong Shou
Journal:  Front Oncol       Date:  2021-12-21       Impact factor: 6.244

7.  Peripheral immune signature resembles tumor microenvironment and predicts clinical outcomes in head and neck squamous cell carcinoma.

Authors:  Zixuan Hu; Jiaying Zhou; Yupeng Li; Yizhao Luan; Huan Li; Bo Jia; Zhi Xie; Bin Cheng; Tong Wu
Journal:  Front Immunol       Date:  2022-09-06       Impact factor: 8.786

Review 8.  Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance.

Authors:  Łukasz Zadka; Damian J Grybowski; Piotr Dzięgiel
Journal:  Cell Oncol (Dordr)       Date:  2020-06-02       Impact factor: 6.730
  8 in total

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