Literature DB >> 30193109

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Samuel F Bakhoum1, Lewis C Cantley2.   

Abstract

Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30193109      PMCID： PMC6136429          DOI： 10.1016/j.cell.2018.08.027

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  111 in total

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Review 6.  Chromothripsis and telomere crisis: engines of genome instability.

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7.  Nuclear Membrane Rupture and Its Consequences.

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