Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae.

Literature DB >> 3018546

Recombination hot spot in the human beta-globin gene cluster: meiotic recombination of human DNA fragments in Saccharomyces cerevisiae.

Abstract

We describe a novel system for the analysis of sequence-specific meiotic recombination in Saccharomyces cerevisiae. A comparison of three adjacent restriction fragments from the human beta-globin locus revealed that one of them, previously hypothesized to contain a relative hot spot for genetic recombination, engages in reciprocal exchange during yeast meiosis significantly more frequently than either of the other two fragments. Removal of the longest of four potential Z-DNA-forming regions from this fragment does not affect the high frequency of genetic recombination.

Entities: Species

Mesh：

Substances：

Year: 1985 PMID： 3018546 PMCID： PMC366921 DOI： 10.1128/mcb.5.8.2029-2038.1985

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

51 in total

1. The mechanism of conversion of deletions and insertions.

Authors: C M Radding
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

2. Symposium on DNA replication and recombination. Summary.

Authors: F W Stahl
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

3. Meiotic gene conversion: a signal of the basic recombination event in yeast.

Authors: S Fogel; R Mortimer; K Lusnak; F Tavares
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

4. Properties of yeast transformation.

Authors: J B Hicks; A Hinnen; G R Fink
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

5. Complete nucleotide sequence of the Escherichia coli plasmid pBR322.

Authors: J G Sutcliffe
Journal: Cold Spring Harb Symp Quant Biol Date: 1979

6. A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human delta and beta globin genes.

Authors: R Miesfeld; M Krystal; N Arnheim
Journal: Nucleic Acids Res Date: 1981-11-25 Impact factor: 16.971

7. DNA sequence homology and chromosomal deletion at a site of SV40 DNA integration.

Authors: J R Stringer
Journal: Nature Date: 1982-03-25 Impact factor: 49.962

8. Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.

Authors: S H Orkin; H H Kazazian; S E Antonarakis; S C Goff; C D Boehm; J P Sexton; P G Waber; P J Giardina
Journal: Nature Date: 1982-04-15 Impact factor: 49.962

9. Hybrid DNA formation during meiotic recombination.

Authors: H Hamza; V Haedens; A Mekki-Berrada; J L Rossignol
Journal: Proc Natl Acad Sci U S A Date: 1981-12 Impact factor: 11.205

10. The DNA sequence of the 5' flanking region of the human beta-globin gene: evolutionary conservation and polymorphic differences.

Authors: N Moschonas; E de Boer; R A Flavell
Journal: Nucleic Acids Res Date: 1982-03-25 Impact factor: 16.971

26 in total

1. d(GA x TC)(n) microsatellite DNA sequences enhance homologous DNA recombination in SV40 minichromosomes.

Authors: A Benet; G Mollà; F Azorín
Journal: Nucleic Acids Res Date: 2000-12-01 Impact factor: 16.971

2. The ubiquitous potential Z-forming sequence of eucaryotes, (dT-dG)n . (dC-dA)n, is not detectable in the genomes of eubacteria, archaebacteria, or mitochondria.

Authors: D S Gross; W T Garrard
Journal: Mol Cell Biol Date: 1986-08 Impact factor: 4.272

3. Nonuniform recombination within the human beta-globin gene cluster: A reply to B. S. Weir and W. G. Hill.

Authors: A Chakravarti; K H Buetow; S E Antonarakis; P G Waber; C D Boehm; H H Kazazian
Journal: Am J Hum Genet Date: 1986-05 Impact factor: 11.025

4. Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast.

Authors: N P Schultes; J W Szostak
Journal: Genetics Date: 1990-12 Impact factor: 4.562

5. A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae.

Authors: N P Schultes; J W Szostak
Journal: Mol Cell Biol Date: 1991-01 Impact factor: 4.272

6. Recombination of haplotypes leads to biased estimates of admixture proportions in human populations.

Authors: R Chakraborty; P E Smouse
Journal: Proc Natl Acad Sci U S A Date: 1988-05 Impact factor: 11.205

7. Evidence for increased recombination near the human insulin gene: implication for disease association studies.

Authors: A Chakravarti; S C Elbein; M A Permutt
Journal: Proc Natl Acad Sci U S A Date: 1986-02 Impact factor: 11.205

8. Polymorphisms of the immunoglobulin heavy-chain delta gene and association with other constant-region genes.

Authors: J C Benger; D W Cox
Journal: Am J Hum Genet Date: 1989-10 Impact factor: 11.025

9. Nonrandom distribution of chloroplast recombination events in Chlamydomonas reinhardtii: evidence for a hotspot and an adjacent cold region.

Authors: S M Newman; E H Harris; A M Johnson; J E Boynton; N W Gillham
Journal: Genetics Date: 1992-10 Impact factor: 4.562

10. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.

Authors: L B Jorde; W S Watkins; M Carlson; J Groden; H Albertsen; A Thliveris; M Leppert
Journal: Am J Hum Genet Date: 1994-05 Impact factor: 11.025