Wilson Oliveira Ezequiel Neto1, Giovana Rodrigues Pereira1,2, Márcia Silva Barbosa3, Natan José Dutra Dias4, Denise Rossato Silva5,6. 1. Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. 2. Setor de Tuberculose, Laboratório Municipal de Alvorada, Alvorada, Brazil. 3. Microbiologia, Faculdade Factum, Porto Alegre, Brazil. 4. Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil. 5. Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. denise.rossato@terra.com.br. 6. Serviço de Pneumologia, Faculdade de Medicina, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 2° Andar, Porto Alegre, RS, CEP 90.035-003, Brazil. denise.rossato@terra.com.br.
Abstract
PURPOSE: Tuberculosis (TB) treatment is often carried out empirically, based on clinical and radiological findings. Chest X-ray (CXR) has good sensitivity but poor specificity in TB diagnosis. Xpert MTB/RIF (Mycobacterium tuberculosis/Rifampicin) is increasingly used in many countries as the initial diagnostic test for TB. The aim of the present study was to evaluate the association of radiological findings with the Xpert MTB/RIF test in patients with suspected pulmonary TB. METHODS: Cross-sectional study in an outpatient TB clinic. Sputum AFB smear, culture, Xpert MTB/RIF, and CXR were collected in patients with suspected pulmonary TB. RESULTS: During the study period, 312 patients met the inclusion criteria and were included in the analysis. Among Xpert MTB/RIF-positive cases, the radiographic patterns were classified as typical of TB, compatible of TB, and normal in 78 (70.3%), 31 (27.9%), and 2 (1.8%) patients, respectively. CXRs were classified as typical of TB, compatible of TB, and normal in 20 (10.0%), 25 (12.4%), and 152 (75.6%) patients, respectively, in Xpert MTB/RIF-negative cases. CONCLUSIONS: We found an association between radiographic patterns and Xpert MTB/RIF results in patients with suspected pulmonary TB. These results confirm the current recommended diagnosis algorithm.
PURPOSE:Tuberculosis (TB) treatment is often carried out empirically, based on clinical and radiological findings. Chest X-ray (CXR) has good sensitivity but poor specificity in TB diagnosis. Xpert MTB/RIF (Mycobacterium tuberculosis/Rifampicin) is increasingly used in many countries as the initial diagnostic test for TB. The aim of the present study was to evaluate the association of radiological findings with the Xpert MTB/RIF test in patients with suspected pulmonary TB. METHODS: Cross-sectional study in an outpatient TB clinic. Sputum AFB smear, culture, Xpert MTB/RIF, and CXR were collected in patients with suspected pulmonary TB. RESULTS: During the study period, 312 patients met the inclusion criteria and were included in the analysis. Among Xpert MTB/RIF-positive cases, the radiographic patterns were classified as typical of TB, compatible of TB, and normal in 78 (70.3%), 31 (27.9%), and 2 (1.8%) patients, respectively. CXRs were classified as typical of TB, compatible of TB, and normal in 20 (10.0%), 25 (12.4%), and 152 (75.6%) patients, respectively, in Xpert MTB/RIF-negative cases. CONCLUSIONS: We found an association between radiographic patterns and Xpert MTB/RIF results in patients with suspected pulmonary TB. These results confirm the current recommended diagnosis algorithm.
Authors: Marcus Barreto Conde; Fernando Augusto Fiuza de Melo; Ana Maria Campos Marques; Ninarosa Calzavara Cardoso; Valeria Goes Ferreira Pinheiro; Paulo de Tarso Roth Dalcin; Almério Machado Junior; Antonio Carlos Moreira Lemos; Antônio Ruffino Netto; Betina Durovni; Clemax Couto Sant'Anna; Dinalva Lima; Domenico Capone; Draurio Barreira; Eliana Dias Matos; Fernanda Carvalho de Queiroz Mello; Fernando Cezar David; Giovanni Marsico; Jorge Barros Afiune; José Roberto Lapa e Silva; Leda Fátima Jamal; Maria Alice da Silva Telles; Mário Hiroyuki Hirata; Margareth Pretti Dalcolmo; Marcelo Fouad Rabahi; Michelle Cailleaux-Cesar; Moises Palaci; Nelson Morrone; Renata Leborato Guerra; Reynaldo Dietze; Silvana Spíndola de Miranda; Solange Cesar Cavalcante; Susie Andries Nogueira; Tatiana Senna Galvão Nonato; Terezinha Martire; Vera Maria Nader Galesi; Valdério do Valle Dettoni Journal: J Bras Pneumol Date: 2009-10 Impact factor: 2.624
Authors: Grant Theron; Lynn Zijenah; Duncan Chanda; Petra Clowes; Andrea Rachow; Maia Lesosky; Wilbert Bara; Stanley Mungofa; Madhukar Pai; Michael Hoelscher; David Dowdy; Alex Pym; Peter Mwaba; Peter Mason; Jonny Peter; Keertan Dheda Journal: Lancet Date: 2013-10-28 Impact factor: 79.321
Authors: Catharina C Boehme; Pamela Nabeta; Doris Hillemann; Mark P Nicol; Shubhada Shenai; Fiorella Krapp; Jenny Allen; Rasim Tahirli; Robert Blakemore; Roxana Rustomjee; Ana Milovic; Martin Jones; Sean M O'Brien; David H Persing; Sabine Ruesch-Gerdes; Eduardo Gotuzzo; Camilla Rodrigues; David Alland; Mark D Perkins Journal: N Engl J Med Date: 2010-09-01 Impact factor: 91.245
Authors: Christine L Heidebrecht; Laura J Podewils; Alexander S Pym; Ted Cohen; Thuli Mthiyane; Douglas Wilson Journal: Sci Rep Date: 2016-01-20 Impact factor: 4.379
Authors: R H H M Philipsen; C I Sánchez; P Maduskar; J Melendez; L Peters-Bax; J G Peter; R Dawson; G Theron; K Dheda; B van Ginneken Journal: Sci Rep Date: 2015-07-27 Impact factor: 4.379