C Wekesa1, B J Kirenga2, M L Joloba3, F Bwanga3, A Katamba2, M R Kamya2. 1. Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda. 2. Department of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda. 3. Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda.
Abstract
SETTING: An out-patient clinic in a country with high rates of tuberculosis-human immunodeficiency virus (TB-HIV) co-infection. DESIGN: Cross-sectional analytical study of 123 adults with chronic cough and no previous anti-tuberculosis treatment. Demographic, clinical, chest X-ray (CXR) and GeneXpert® MTB/RIF data were collected. Proportions of TB diagnoses using both tests were calculated and compared using an unpaired t-test. RESULTS: Sixty-six patients (53.7%) were female and 35 (28.5%) tested positive for HIV; 21 (17.1%) were Xpert-positive, while 51 (42.5%) had CXR suggestive of TB (P = 0.0018), of whom only 15 (29.4%) were Xpert-positive. CXR was suggestive of pulmonary TB in 15 (71.4%) of the 21 patients with a positive Xpert test. CONCLUSIONS: The majority of the sputum smear-negative patients did not have TB on single Xpert testing. CXR gave an overestimate of sputum smear-negative TB cases.
SETTING: An out-patient clinic in a country with high rates of tuberculosis-human immunodeficiency virus (TB-HIV) co-infection. DESIGN: Cross-sectional analytical study of 123 adults with chronic cough and no previous anti-tuberculosis treatment. Demographic, clinical, chest X-ray (CXR) and GeneXpert® MTB/RIF data were collected. Proportions of TB diagnoses using both tests were calculated and compared using an unpaired t-test. RESULTS: Sixty-six patients (53.7%) were female and 35 (28.5%) tested positive for HIV; 21 (17.1%) were Xpert-positive, while 51 (42.5%) had CXR suggestive of TB (P = 0.0018), of whom only 15 (29.4%) were Xpert-positive. CXR was suggestive of pulmonary TB in 15 (71.4%) of the 21 patients with a positive Xpert test. CONCLUSIONS: The majority of the sputum smear-negative patients did not have TB on single Xpert testing. CXR gave an overestimate of sputum smear-negative TB cases.
Authors: Simon Walusimbi; Fred Semitala; Freddie Bwanga; Melles Haile; Ayesha De Costa; Lucian Davis; Moses Joloba; Sven Hoffner; Moses Kamya Journal: Pan Afr Med J Date: 2016-03-31
Authors: Zaiyad G Habib; Farouq M Dayyab; Abdallah Sanda; Sirajo H Tambuwal; Mahmood M Dalhat; Hamza Muhammad; Garba Iliyasu; Ibrahim Nashabaru; Abdulrazaq G Habib Journal: Case Rep Infect Dis Date: 2015-08-03