Literature DB >> 30159708

Limited MHC class II gene polymorphism in the West African chimpanzee is distributed maximally by haplotype diversity.

Nel Otting1,2, Natasja G de Groot3,4, Ronald E Bontrop3,4,5.   

Abstract

Chimpanzees have been used for some time as an animal model in research on immune-related diseases in humans. The major histocompatibility complex (MHC) region of the chimpanzee has also been the subject of studies in which the attention was mainly on the class I genes. Although full-length sequence information is available on the DRB region genes, such detailed information is lacking for the other class II genes and, if present, is based mainly on exon 2 sequences. In the present study, full-length sequencing was performed on DQ, DP, and DRA genes in a cohort of 67 pedigreed animals, thereby allowing a thorough analysis of the MHC class II repertoire. The results demonstrate that the number of MHC class II lineages and alleles is relatively low, whereas haplotype diversity (combination of genes/alleles on a chromosome) seems to have been maximised by crossing-over processes.

Entities:  

Keywords:  Chimpanzee; MHC; Nonhuman primates

Mesh：

Substances：

Year:  2018        PMID： 30159708     DOI： 10.1007/s00251-018-1080-4

Source DB:  PubMed          Journal:  Immunogenetics        ISSN： 0093-7711            Impact factor:   2.846


  39 in total

1.  HLA-DR beta genes vary in number between different DR specificities, whereas the number of DQ beta genes is constant.

Authors:  J Böhme; M Andersson; G Andersson; E Möller; P A Peterson; L Rask
Journal:  J Immunol       Date:  1985-09       Impact factor: 5.422

Review 2.  AIDS in chimpanzees: the role of MHC genes.

Authors:  Natasja G de Groot; Corinne M C Heijmans; Ronald E Bontrop
Journal:  Immunogenetics       Date:  2017-07-10       Impact factor: 2.846

Review 3.  Differential evolutionary MHC class II strategies in humans and rhesus macaques: relevance for biomedical studies.

Authors:  G G Doxiadis; N Otting; N G de Groot; R E Bontrop
Journal:  Immunol Rev       Date:  2001-10       Impact factor: 12.988

4.  The orthologs of HLA-DQ and -DP genes display abundant levels of variability in macaque species.

Authors:  Nel Otting; Marit K H van der Wiel; Nanine de Groot; Annemiek J M de Vos-Rouweler; Natasja G de Groot; Gaby G M Doxiadis; Roger W Wiseman; David H O'Connor; Ronald E Bontrop
Journal:  Immunogenetics       Date:  2016-10-22       Impact factor: 2.846

5.  Major histocompatibility complex class I diversity in a West African chimpanzee population: implications for HIV research.

Authors:  N G de Groot; N Otting; R Argüello; D I Watkins; G G Doxiadis; J A Madrigal; R E Bontrop
Journal:  Immunogenetics       Date:  2000-05       Impact factor: 2.846

Review 6.  Major histocompatibility complex class II haplotypes in a breeding colony of chimpanzees (Pan troglodytes).

Authors:  B L Slierendregt; M Kenter; N Otting; J Anholts; M Jonker; R E Bontrop
Journal:  Tissue Antigens       Date:  1993-08

7.  Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees.

Authors:  Natasja G de Groot; Nel Otting; Gaby G M Doxiadis; Sunita S Balla-Jhagjhoorsingh; Jonathan L Heeney; Jon J van Rood; Pascal Gagneux; Ronald E Bontrop
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-19       Impact factor: 11.205

8.  The chimpanzee Mhc-DRB region revisited: gene content, polymorphism, pseudogenes, and transcripts.

Authors:  Natasja G de Groot; Corrine M C Heijmans; Nanine de Groot; Gaby G M Doxiadis; Nel Otting; Ronald E Bontrop
Journal:  Mol Immunol       Date:  2009-10-02       Impact factor: 4.407

9.  Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence.

Authors:  Tatsuya Anzai; Takashi Shiina; Natsuki Kimura; Kazuyo Yanagiya; Sakae Kohara; Atsuko Shigenari; Tetsushi Yamagata; Jerzy K Kulski; Taeko K Naruse; Yoshifumi Fujimori; Yasuhito Fukuzumi; Masaaki Yamazaki; Hiroyuki Tashiro; Chie Iwamoto; Yumi Umehara; Tadashi Imanishi; Alice Meyer; Kazuho Ikeo; Takashi Gojobori; Seiamak Bahram; Hidetoshi Inoko
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-10       Impact factor: 11.205

10.  MHC class I diversity in chimpanzees and bonobos.

Authors:  Vincent Maibach; Jörg B Hans; Christina Hvilsom; Tomas Marques-Bonet; Linda Vigilant
Journal:  Immunogenetics       Date:  2017-06-16       Impact factor: 2.846
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  3 in total

1.  Nomenclature report 2019: major histocompatibility complex genes and alleles of Great and Small Ape and Old and New World monkey species.

Authors:  Natasja G de Groot; Nel Otting; Giuseppe Maccari; James Robinson; John A Hammond; Antoine Blancher; Bernard A P Lafont; Lisbeth A Guethlein; Emily E Wroblewski; Steven G E Marsh; Takashi Shiina; Lutz Walter; Linda Vigilant; Peter Parham; David H O'Connor; Ronald E Bontrop
Journal:  Immunogenetics       Date:  2019-10-17       Impact factor: 2.846

2.  Binding affinities of 438 HLA proteins to complete proteomes of seven pandemic viruses and distributions of strongest and weakest HLA peptide binders in populations worldwide.

Authors:  Rodrigo Barquera; Evelyn Collen; Da Di; Stéphane Buhler; João Teixeira; Bastien Llamas; José M Nunes; Alicia Sanchez-Mazas
Journal:  HLA       Date:  2020-06-11       Impact factor: 8.762

3.  Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans indicate highly conserved mechanisms of MHC molecular evolution.

Authors:  Christelle Vangenot; José Manuel Nunes; Gaby M Doxiadis; Estella S Poloni; Ronald E Bontrop; Natasja G de Groot; Alicia Sanchez-Mazas
Journal:  BMC Evol Biol       Date:  2020-09-15       Impact factor: 3.260
  3 in total

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