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Literature DB >> 3015000

Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa.

Abstract

Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibits the ability of P. aeruginosa DNA gyrase to supercoil relaxed, closed circular DNA in vitro. At intermediate concentrations of the drug, inhibition of DNA replication in vivo is followed by secondary (recovery) synthesis. Both recovery synthesis and the bactericidal effects of norfloxacin are dependent on continued protein synthesis, suggesting that these are inducible functions. Neither norfloxacin nor nalidixic acid induces Weigle-reactivation (inducible DNA repair) or mutagenesis in P. aeruginosa.

Entities: Chemical Disease Species

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Year: 1986 PMID： 3015000 PMCID： PMC180353 DOI： 10.1128/AAC.29.1.1

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. DNA gyrase: an enzyme that introduces superhelical turns into DNA.

Authors: M Gellert; K Mizuuchi; M H O'Dea; H A Nash
Journal: Proc Natl Acad Sci U S A Date: 1976-11 Impact factor: 11.205

2. [Prophage induction and cell division in E. coli. II. Linked (recA, zab) and unlinked (lex) suppressors of tif-1-mediated induction and filamentation].

Authors: M Castellazzi; J George; G Buttin
Journal: Mol Gen Genet Date: 1972

3. Bactericidal effect against Escherichia coli of nalidixic acid and four structurally related compounds.

Authors: P J Stevens
Journal: J Antimicrob Chemother Date: 1980-07 Impact factor: 5.790

4. Prophage induction and cell division in E. coli. III. Mutations sfiA and sfiB restore division in tif and lon strains and permit the expression of mutator properties of tif.

Authors: J George; M Castellazzi; G Buttin
Journal: Mol Gen Genet Date: 1975-10-22

Review 5. Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

Authors: E M Witkin
Journal: Bacteriol Rev Date: 1976-12

6. Genetic circularity of the Pseudomonas aeruginosa PAO chromosome.

Authors: P L Royle; H Matsumoto; B W Holloway
Journal: J Bacteriol Date: 1981-01 Impact factor: 3.490

7. Characterization of Pseudomonas aeruginosa mutants deficient in the establishment of lysogeny.

Authors: R V Miller; C M Ku
Journal: J Bacteriol Date: 1978-06 Impact factor: 3.490

8. ANALYSIS OF A GENE CONTROLLING CELL DIVISION AND SENSITIVITY TO RADIATION IN ESCHERICHIA COLI.

Authors: H I ADLER; A A HARDIGREE
Journal: J Bacteriol Date: 1964-03 Impact factor: 3.490

9. In vitro antibacterial activity of AM-715, a new nalidixic acid analog.

Authors: A Ito; K Hirai; M Inoue; H Koga; S Suzue; T Irikura; S Mitsuhashi
Journal: Antimicrob Agents Chemother Date: 1980-02 Impact factor: 5.191

10. DNA gyrase: affinity chromatography on novobiocin-Sepharose and catalytic properties.

Authors: W L Staudenbauer; E Orr
Journal: Nucleic Acids Res Date: 1981-08-11 Impact factor: 16.971

28 in total

1. A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.

Authors: L J Piddock; M C Hall; F Bellido; M Bains; R E Hancock
Journal: Antimicrob Agents Chemother Date: 1992-05 Impact factor: 5.191

Review 2. Structure-activity relationships of the fluoroquinolones.

Authors: D T Chu; P B Fernandes
Journal: Antimicrob Agents Chemother Date: 1989-02 Impact factor: 5.191

3. Resistance to pefloxacin in Pseudomonas aeruginosa.

Authors: M Michea-Hamzehpour; C Lucain; J C Pechere
Journal: Antimicrob Agents Chemother Date: 1991-03 Impact factor: 5.191

Review 4. Discovery and development of new antimicrobial agents.

Authors: T D Gootz
Journal: Clin Microbiol Rev Date: 1990-01 Impact factor: 26.132

5. Some properties of subunits of DNA gyrase from Pseudomonas aeruginosa PAO1 and its nalidixic acid-resistant mutant.

Authors: Y Inoue; K Sato; T Fujii; K Hirai; M Inoue; S Iyobe; S Mitsuhashi
Journal: J Bacteriol Date: 1987-05 Impact factor: 3.490

6. Computer automated structure evaluation of quinolone antibacterial agents.

Authors: G Klopman; O T Macina; M E Levinson; H S Rosenkranz
Journal: Antimicrob Agents Chemother Date: 1987-11 Impact factor: 5.191

7. Clinical uses of nalidixic acid analogues: the fluoroquinolones.

Authors: N Høiby
Journal: Eur J Clin Microbiol Date: 1986-04 Impact factor: 3.267

8. Mechanism of action of sparfloxacin against and mechanism of resistance in gram-negative and gram-positive bacteria.

Authors: L J Piddock; M Zhu
Journal: Antimicrob Agents Chemother Date: 1991-11 Impact factor: 5.191

9. Contribution of permeability and sensitivity to inhibition of DNA synthesis in determining susceptibilities of Escherichia coli, Pseudomonas aeruginosa, and Alcaligenes faecalis to ciprofloxacin.

Authors: J Bedard; S Chamberland; S Wong; T Schollaardt; L E Bryan
Journal: Antimicrob Agents Chemother Date: 1989-09 Impact factor: 5.191

10. Ciprofloxacin resistance in clinical isolates of Salmonella typhimurium obtained from two patients.

Authors: L J Piddock; D J Griggs; M C Hall; Y F Jin
Journal: Antimicrob Agents Chemother Date: 1993-04 Impact factor: 5.191