Literature DB >> 2829716

Computer automated structure evaluation of quinolone antibacterial agents.

G Klopman1, O T Macina, M E Levinson, H S Rosenkranz.   

Abstract

The Computer Automated Structure Evaluation (CASE) program was used to study a series of quinolone antibacterial agents for which experimental data pertaining to DNA gyrase inhibition as well as MICs against several strains of gram-positive and gram-negative bacteria are available. The result of the analysis was the automatic generation of molecular fragments relevant to the respective biological endpoints. The potential significance of these major activating-inactivating fragments to the biological activity is discussed.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2829716      PMCID： PMC175048          DOI： 10.1128/AAC.31.11.1831

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  A MATHEMATICAL CONTRIBUTION TO STRUCTURE-ACTIVITY STUDIES.

Authors:  S M FREE; J W WILSON
Journal:  J Med Chem       Date:  1964-07       Impact factor: 7.446

2.  New nalidixic acid resistance mutations related to deoxyribonucleic acid gyrase activity.

Authors:  J Yamagishi; Y Furutani; S Inoue; T Ohue; S Nakamura; M Shimizu
Journal:  J Bacteriol       Date:  1981-11       Impact factor: 3.490

3.  Use of artificial intelligence in structure-activity correlations of anticonvulsant drugs.

Authors:  G Klopman; R Contreras
Journal:  Mol Pharmacol       Date:  1985-01       Impact factor: 4.436

4.  Use of the Computer Automated Structure Evaluation program in determining quantitative structure-activity relationships within hallucinogenic phenylalkylamines.

Authors:  G Klopman; O T Macina
Journal:  J Theor Biol       Date:  1985-04-21       Impact factor: 2.691

5.  Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12.

Authors:  K Hirai; H Aoyama; S Suzue; T Irikura; S Iyobe; S Mitsuhashi
Journal:  Antimicrob Agents Chemother       Date:  1986-08       Impact factor: 5.191

6.  Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids.

Authors:  H Koga; A Itoh; S Murayama; S Suzue; T Irikura
Journal:  J Med Chem       Date:  1980-12       Impact factor: 7.446

7.  Structure-activity relationships among DNA gyrase inhibitors. Synthesis and biological evaluation of 1,2-dihydro-4, 4-dimethyl-1-oxo-2-naphthalenecarboxylic acids as 1-carba bioisosteres of oxolinic acid.

Authors:  T Högberg; I Khanna; S D Drake; L A Mitscher; L L Shen
Journal:  J Med Chem       Date:  1984-03       Impact factor: 7.446

8.  Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

Authors:  M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

9.  Nalidixic Acid and the Metabolism of Escherichia coli.

Authors:  E B Winshell; H S Rosenkranz
Journal:  J Bacteriol       Date:  1970-12       Impact factor: 3.490

10.  Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents.

Authors:  D T Chu; P B Fernandes; A K Claiborne; E Pihuleac; C W Nordeen; R E Maleczka; A G Pernet
Journal:  J Med Chem       Date:  1985-11       Impact factor: 7.446
View more
  17 in total

1.  Computer Automated Structure Evaluation (CASE) of the teratogenicity of retinoids with the aid of a novel geometry index.

Authors:  G Klopman; M L Dimayuga
Journal:  J Comput Aided Mol Des       Date:  1990-06       Impact factor: 3.686

Review 2.  Structure-activity relationships of the fluoroquinolones.

Authors:  D T Chu; P B Fernandes
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

Review 3.  Inhibitory effects of quinolone antibacterial agents on eucaryotic topoisomerases and related test systems.

Authors:  T D Gootz; J F Barrett; J A Sutcliffe
Journal:  Antimicrob Agents Chemother       Date:  1990-01       Impact factor: 5.191

4.  Interaction of the fluoroquinolone antimicrobial agents ciprofloxacin and enoxacin with liposomes.

Authors:  J Bedard; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

5.  Anti-Mycobacterium avium activity of quinolones: in vitro activities.

Authors:  G Klopman; S Wang; M R Jacobs; S Bajaksouzian; K Edmonds; J J Ellner
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

Review 6.  Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.

Authors:  H Nikaido; D G Thanassi
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

7.  Contribution of permeability and sensitivity to inhibition of DNA synthesis in determining susceptibilities of Escherichia coli, Pseudomonas aeruginosa, and Alcaligenes faecalis to ciprofloxacin.

Authors:  J Bedard; S Chamberland; S Wong; T Schollaardt; L E Bryan
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

Review 8.  Quinolones in urology.

Authors:  K T Nielsen; P O Madsen
Journal:  Urol Res       Date:  1989

9.  Relationships among antibacterial activity, inhibition of DNA gyrase, and intracellular accumulation of 11 fluoroquinolones.

Authors:  S Bazile; N Moreau; D Bouzard; M Essiz
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

10.  Anti-Mycobacterium avium activity of quinolones: structure-activity relationship studies.

Authors:  G Klopman; S Wang; M R Jacobs; J J Ellner
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.