Literature DB >> 3013793

Chromosome aberrations induced in human lymphocytes by 8.7 MeV protons and 23.5 MeV helium-3 ions.

A A Edwards, D C Lloyd, J S Prosser, P Finnon, J E Moquet.   

Abstract

This paper describes the irradiation of thin samples of blood with 8.7 MeV protons and 23.5 MeV helium-3 ions in the track segment mode. Chromosome aberrations in human lymphocytes have been scored. The relationship between dicentric yield and dose in Gy was Y = 0.044 D + 0.058 D2 for protons and Y = 0.394 D for helium ions. These results are compared with data from other laboratories using protons and an attempt is made to reconcile differences. An unexpected observation was that the ratio of the linear coefficients for helium ions and protons was about 9 whereas the ratio of the l.e.t. values was 4.5. This disagrees with current theory which predicts that the linear coefficients should be proportional to l.e.t. Possible sources of error in our experiments are discussed but do not adequately account for the discrepancies.

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Year:  1986        PMID: 3013793     DOI: 10.1080/09553008614550511

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN: 0020-7616


  7 in total

Review 1.  First steps towards systems radiation biology studies concerned with DNA and chromosome structure within living cells.

Authors:  Werner Friedland; Herwig G Paretzke; Francesca Ballarini; Andrea Ottolenghi; Gregor Kreth; Christoph Cremer
Journal:  Radiat Environ Biophys       Date:  2008-01-10       Impact factor: 1.925

2.  Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.

Authors:  Hongyu Zhu; Aimee L McNamara; Stephen J McMahon; Jose Ramos-Mendez; Nicholas T Henthorn; Bruce Faddegon; Kathryn D Held; Joseph Perl; Junli Li; Harald Paganetti; Jan Schuemann
Journal:  Radiat Res       Date:  2020-07-08       Impact factor: 2.841

3.  DNA damage in non-proliferating cells subjected to ionizing irradiation at high or low dose rates.

Authors:  R K Sachs; P Chen; P Hahnfeldt; D Lai; L R Hlatky
Journal:  J Math Biol       Date:  1993       Impact factor: 2.259

4.  Background Level of Unstable Chromosome Aberrations in the Kazakhstan Population: A Human Biomonitoring Study.

Authors:  Laura B Kenzhina; Aigul N Mamyrbayeva; Sergey N Lukashenko; Zhanat A Baigazinov; Dina B Biyakhmetova; Andrey V Panitskiy; Elena Polivkina; Fail F Zhamaldinov; Clarice Patrono; Valentina Palma; Antonella Testa
Journal:  Int J Environ Res Public Health       Date:  2022-07-12       Impact factor: 4.614

5.  Hodgkin's lymphoma emerging radiation treatment techniques: trade-offs between late radio-induced toxicities and secondary malignant neoplasms.

Authors:  Laura Cella; Manuel Conson; Maria Cristina Pressello; Silvia Molinelli; Uwe Schneider; Vittorio Donato; Roberto Orecchia; Marco Salvatore; Roberto Pacelli
Journal:  Radiat Oncol       Date:  2013-01-30       Impact factor: 3.481

6.  Biological Effectiveness of Accelerated Protons for Chromosome Exchanges.

Authors:  Kerry A George; Megumi Hada; Francis A Cucinotta
Journal:  Front Oncol       Date:  2015-10-19       Impact factor: 6.244

7.  Comparing second cancer risk for multiple radiotherapy modalities in survivors of hodgkin lymphoma.

Authors:  Claire Timlin; James Loken; Jon Kruse; Robert Miller; Uwe Schneider
Journal:  Br J Radiol       Date:  2021-04-09       Impact factor: 3.039

  7 in total

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