Yong Zhang1, Jin Guo2, Yangyang Duanmu1, Chenxin Zhang1, Wei Zhao1, Ling Wang1, Xiaoguang Cheng1, Nicola Veronese3, Francesco Pio Cafarelli4, Giuseppe Guglielmi5,6. 1. Department of Radiology, Beijing Jishuitan Hospital, Beijing, 100035, China. 2. School of Public Health, Capital Medical University, Beijing, 100069, China. 3. National Research Council, Neuroscience Institute, Aging Branch, Padua, Italy. 4. Department of Radiology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy. 5. Department of Radiology, University of Foggia, Viale Luigi Pinto 1, 71100, Foggia, Italy. giuseppe.guglielmi@unifg.it. 6. Department of Radiology, Scientific Institute "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Foggia, Italy. giuseppe.guglielmi@unifg.it.
Abstract
OBJECTIVES: Bone mineral density (BMD) is associated with muscle mass and quality, but little research has been done on functional muscle-bone unit and back muscle density in patients with lumbar vertebral fracture. This study used the "modified functional muscle-bone unit" concept and measured back muscle density to investigate muscle-bone interaction difference between the fracture and control group. METHODS: This was a case-control study. A total of 52 elderly male patients (mean age 75 years) with lumbar vertebral fracture (cases) and 52 control healthy subjects were enrolled. Cross-sectional area (CSA) and density of paravertebral muscle were measured in quantitative computed tomography (QCT) images to represent the muscle mass, while the bone mineral density measured by QCT was used to represent the bone mass. The modified functional muscle-bone unit was calculated as the value of volumetric BMD divided by muscle area. RESULTS: People with vertebral fractures reported significantly lower values in the cross-sectional area and density of paravertebral muscle compared to control group. In the multivariate analysis, BMD (odds ratio, OR = 0.929; 95% confidence intervals, CIs 0.888-0.971), erector muscle density (OR = 0.698; 95% CI 0.547-0.892), and summated muscle CSA (OR = 0.963; 95% CI 0.93-0.991) were independent protective factors for the presence of a fracture. BMD resulted significantly and moderately associated with cross-sectional area and density of paravertebral muscle (r = 0.329-0.396). CONCLUSIONS: There were significant differences between the modified functional muscle-bone unit and back muscle density between the fracture group and control group in elderly men. Lower BMD, loss of muscle mass and density are associated with increased presence of the lumbar vertebral fracture.
OBJECTIVES: Bone mineral density (BMD) is associated with muscle mass and quality, but little research has been done on functional muscle-bone unit and back muscle density in patients with lumbar vertebral fracture. This study used the "modified functional muscle-bone unit" concept and measured back muscle density to investigate muscle-bone interaction difference between the fracture and control group. METHODS: This was a case-control study. A total of 52 elderly male patients (mean age 75 years) with lumbar vertebral fracture (cases) and 52 control healthy subjects were enrolled. Cross-sectional area (CSA) and density of paravertebral muscle were measured in quantitative computed tomography (QCT) images to represent the muscle mass, while the bone mineral density measured by QCT was used to represent the bone mass. The modified functional muscle-bone unit was calculated as the value of volumetric BMD divided by muscle area. RESULTS:People with vertebral fractures reported significantly lower values in the cross-sectional area and density of paravertebral muscle compared to control group. In the multivariate analysis, BMD (odds ratio, OR = 0.929; 95% confidence intervals, CIs 0.888-0.971), erector muscle density (OR = 0.698; 95% CI 0.547-0.892), and summated muscle CSA (OR = 0.963; 95% CI 0.93-0.991) were independent protective factors for the presence of a fracture. BMD resulted significantly and moderately associated with cross-sectional area and density of paravertebral muscle (r = 0.329-0.396). CONCLUSIONS: There were significant differences between the modified functional muscle-bone unit and back muscle density between the fracture group and control group in elderly men. Lower BMD, loss of muscle mass and density are associated with increased presence of the lumbar vertebral fracture.
Authors: Chien-Chou Pan; Peter Simon; Alejandro A Espinoza Orías; Ryota Takatori; Howard S An; Gunnar B J Andersson; Nozomu Inoue Journal: Skeletal Radiol Date: 2019-10-30 Impact factor: 2.199
Authors: Dagmar Schaffler-Schaden; Christoph Kneidinger; Gregor Schweighofer-Zwink; Maria Flamm; Bernhard Iglseder; Christian Pirich Journal: Skeletal Radiol Date: 2020-01-24 Impact factor: 2.199