Literature DB >> 30112994

A Review on Recent Synthetic Strategies and Pharmacological Importance of 1,3-Thiazole Derivatives.

Swarnagowri Nayak1, Santhosh L Gaonkar1.   

Abstract

Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug design. Presence of several reaction sites in the thiazole moiety extends their range of applications and leads to new solutions for challenges in synthetic and medicinal chemistry. Thiazole derivatives are widely used as bioactive agents, liquid crystals, sensors, catalysts, etc. The motivating molecular architecture of 1,3-thiazoles makes them suitable moieties for drug development. In this review, our aim is to corroborate the recent data available on various synthetic strategies and biological properties of 1,3- thiazole derivatives. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  2,4,5-substituted thiazole; 2,4-substituted thiazole; 2,5-substituted thiazole; 2-substituted thiazole; anti-cancer activity; anti-microbial activity; antioxidant activity; fused thiazole.

Mesh：

Substances：

Year:  2019        PMID： 30112994     DOI： 10.2174/1389557518666180816112151

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  14 in total

1.  Mono-Alkylated Ligands Based on Pyrazole and Triazole Derivatives Tested Against Fusarium oxysporum f. sp. albedinis: Synthesis, Characterization, DFT, and Phytase Binding Site Identification Using Blind Docking/Virtual Screening for Potent Fophy Inhibitors.

Authors:  Yassine Kaddouri; Farid Abrigach; Sabir Ouahhoud; Redouane Benabbes; Mohamed El Kodadi; Ali Alsalme; Nabil Al-Zaqri; Ismail Warad; Rachid Touzani
Journal:  Front Chem       Date:  2020-12-11       Impact factor: 5.221

2.  Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety.

Authors:  Amr S Abouzied; Jehan Y Al-Humaidi; Abdulrahman S Bazaid; Husam Qanash; Naif K Binsaleh; Abdulwahab Alamri; Sheikh Muhammad Ibrahim; Sobhi M Gomha
Journal:  Molecules       Date:  2022-09-27       Impact factor: 4.927

3.  Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies.

Authors:  Nisha Poonia; Kashmiri Lal; Ashwani Kumar; Anil Kumar; Srikanta Sahu; Anurag T K Baidya; Rajnish Kumar
Journal:  Mol Divers       Date:  2021-10-20       Impact factor: 3.364

4.  Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights.

Authors:  Tarfah Al-Warhi; Ahmed M El Kerdawy; Mohamed A Said; Amgad Albohy; Zainab M Elsayed; Nada Aljaeed; Eslam B Elkaeed; Wagdy M Eldehna; Hatem A Abdel-Aziz; Miral A Abdelmoaz
Journal:  Drug Des Devel Ther       Date:  2022-05-16       Impact factor: 4.319

Review 5.  Thiazole Ring-A Biologically Active Scaffold.

Authors:  Anthi Petrou; Maria Fesatidou; Athina Geronikaki
Journal:  Molecules       Date:  2021-05-25       Impact factor: 4.411

6.  Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) tethered to nano-Fe3O4 as a superior catalyst for the synthesis of 1,3-thiazoles.

Authors:  Hossein Shahbazi-Alavi; Sheida Khojasteh-Khosro; Javad Safaei-Ghomi; Maryam Tavazo
Journal:  BMC Chem       Date:  2019-10-12

7.  One-Pot Synthesis of Novel Thiazoles as Potential Anti-Cancer Agents.

Authors:  Abdelwahed R Sayed; Sobhi M Gomha; Eman A Taher; Zeinab A Muhammad; Hesham R El-Seedi; Hatem M Gaber; Mahgoub M Ahmed
Journal:  Drug Des Devel Ther       Date:  2020-04-03       Impact factor: 4.162

Review 8.  An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives.

Authors:  Anca-Maria Borcea; Ioana Ionuț; Ovidiu Crișan; Ovidiu Oniga
Journal:  Molecules       Date:  2021-01-25       Impact factor: 4.411

9.  Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole-Thiophene Scaffolds.

Authors:  Sobhi M Gomha; Sayed M Riyadh; Bader Huwaimel; Mohie E M Zayed; Magda H Abdellattif
Journal:  Molecules       Date:  2022-07-20       Impact factor: 4.927

10.  Sulfur-containing therapeutics in the treatment of Alzheimer's disease.

Authors:  Haizhou Zhu; Venkateshwara Dronamraju; Wei Xie; Swati S More
Journal:  Med Chem Res       Date:  2021-01-15       Impact factor: 1.965
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