BACKGROUND: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. Indeed, the thiazole scaffold is contained in more than 18 FDA-approved drugs as well as in numerous experimental drugs. OBJECTIVE: To summarize recent literature on the biological activities of thiazole ring-containing compounds Methods: A literature survey regarding the topics from the year 2015 up to now was carried out. Older publications were not included, since they were previously analyzed in available peer reviews. RESULTS: Nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
BACKGROUND:Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. Indeed, the thiazole scaffold is contained in more than 18 FDA-approved drugs as well as in numerous experimental drugs. OBJECTIVE: To summarize recent literature on the biological activities of thiazole ring-containing compounds Methods: A literature survey regarding the topics from the year 2015 up to now was carried out. Older publications were not included, since they were previously analyzed in available peer reviews. RESULTS:Nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
Authors: B Narasimhulu Naidu; Margaret E Sorenson; Yunhui Zhang; Oak K Kim; John D Matiskella; John A Wichtowski; Timothy P Connolly; Wenying Li; Kin S Lam; Joanne J Bronson; Michael J Pucci; Junius M Clark; Yasutsugu Ueda Journal: Bioorg Med Chem Lett Date: 2004-11-15 Impact factor: 2.823
Authors: Krzysztof Z Łączkowski; Anna Biernasiuk; Angelika Baranowska-Łączkowska; Sylwia Zielińska; Kinga Sałat; Anna Furgała; Konrad Misiura; Anna Malm Journal: J Enzyme Inhib Med Chem Date: 2016-05-19 Impact factor: 5.051
Authors: Ashraf A Aly; Stefan Bräse; Alaa A Hassan; Nasr K Mohamed; Lamiaa E Abd El-Haleem; Martin Nieger; Nesrin M Morsy; Mohammed B Alshammari; Mahmoud A A Ibrahim; Elshimaa M N Abdelhafez Journal: Molecules Date: 2020-11-27 Impact factor: 4.411
Authors: Mohammed F Arshad; Aftab Alam; Abdullah Ayed Alshammari; Mohammed Bader Alhazza; Ibrahim Mohammed Alzimam; Md Anish Alam; Gulam Mustafa; Md Salahuddin Ansari; Abdulelah M Alotaibi; Abdullah A Alotaibi; Suresh Kumar; Syed Mohammed Basheeruddin Asdaq; Mohd Imran; Pran Kishore Deb; Katharigatta N Venugopala; Shahamah Jomah Journal: Molecules Date: 2022-06-21 Impact factor: 4.927
Authors: Mohammad Y Alfaifi; Ali A Shati; Serag Eldin I Elbehairi; Reda F M Elshaarawy; Emad M Gad Journal: RSC Adv Date: 2021-12-22 Impact factor: 3.361
Authors: Manar G Salem; Dina M Abu El-Maaty; Yassmina I Mohey El-Deen; Basem H Elesawy; Ahmad El Askary; Asmaa Saleh; Essa M Saied; Mohammed El Behery Journal: Molecules Date: 2022-07-31 Impact factor: 4.927