Literature DB >> 30108754

Synthesis and DNA/RNA complementation studies of peptide nucleic acids containing 5-halouracils.

Chun-Dong Liu1, Jian-Hua Wang1, Yang Xie1, Hang Chen1.   

Abstract

The monomers of peptide nucleic acids containing 5-halouracils (5-XU-PNA), incorporated into heptameric PNA in the middle position, have been synthesized. Thermodynamic analyses revealed that the heptameric PNA oligomer with DNA and RNA showed higher duplex stability compared to the unmodified PNA counterpart. NMR studies suggested that the electron withdrawing effect of the halogen atom increased the strength of the XU-A hydrogen bond.

Entities:  

Year:  2016        PMID： 30108754      PMCID： PMC6071789          DOI： 10.1039/c6md00536e

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  15 in total

1.  Synthesis and hybridization properties of DNA-PNA chimeras carrying 5-bromouracil and 5-methylcytosine.

Authors:  E Ferrer; A Shevchenko; R Eritja
Journal:  Bioorg Med Chem       Date:  2000-02       Impact factor: 3.641

2.  1H NMR determination of base-pair lifetimes in oligonucleotides containing single base mismatches.

Authors:  Pratip K Bhattacharya; Julie Cha; Jacqueline K Barton
Journal:  Nucleic Acids Res       Date:  2002-11-01       Impact factor: 16.971

3.  Fluorinated Peptide Nucleic Acids with Fluoroacetyl Side Chain Bearing 5-(F/CF3)-Uracil: Synthesis and Cell Uptake Studies.

Authors:  Satheesh Ellipilli; Sandeep Palvai; Krishna N Ganesh
Journal:  J Org Chem       Date:  2016-07-22       Impact factor: 4.354

4.  Stereospecific backbone methylation of pyrrolidine-amide oligonucleotide mimics (POM).

Authors:  Anila I Khan; T H Samuel Tan; Jason Micklefield
Journal:  Chem Commun (Camb)       Date:  2006-02-23       Impact factor: 6.222

Review 5.  [Development of artificial nucleic acids functionalized for damaged gene diagnosis, gene inhibition and delivery system].

Authors:  Osamu Nakagawa
Journal:  Yakugaku Zasshi       Date:  2014       Impact factor: 0.302

6.  Fluorous Peptide Nucleic Acids: PNA Analogues with Fluorine in Backbone (γ-CF2-apg-PNA) Enhance Cellular Uptake.

Authors:  Satheesh Ellipilli; Krishna N Ganesh
Journal:  J Org Chem       Date:  2015-09-08       Impact factor: 4.354

7.  Base pairing configuration and stability of an oligonucleotide duplex containing a 5-chlorouracil-adenine base pair.

Authors:  Jacob A Theruvathu; Cherine H Kim; Daniel K Rogstad; Jonathan W Neidigh; Lawrence C Sowers
Journal:  Biochemistry       Date:  2009-08-11       Impact factor: 3.162

8.  Comparison of the structural and dynamic effects of 5-methylcytosine and 5-chlorocytosine in a CpG dinucleotide sequence.

Authors:  Jacob A Theruvathu; Y Whitney Yin; B Montgomery Pettitt; Lawrence C Sowers
Journal:  Biochemistry       Date:  2013-11-11       Impact factor: 3.162

9.  Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide.

Authors:  P E Nielsen; M Egholm; R H Berg; O Buchardt
Journal:  Science       Date:  1991-12-06       Impact factor: 47.728

10.  A polymeric prodrug of 5-fluorouracil-1-acetic acid using a multi-hydroxyl polyethylene glycol derivative as the drug carrier.

Authors:  Man Li; Zhen Liang; Xun Sun; Tao Gong; Zhirong Zhang
Journal:  PLoS One       Date:  2014-11-12       Impact factor: 3.240
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  3 in total

1.  Self-assembled nanoparticles for cellular delivery of peptide nucleic acid using amphiphilic N,N,N-trimethyl-O-alkyl chitosan derivatives.

Authors:  Chundong Liu; Jianhua Wang; Sheng Huang; Lin Yu; Yan Wang; Hang Chen; Dong Wang
Journal:  J Mater Sci Mater Med       Date:  2018-07-17       Impact factor: 3.896

2.  Structural Insights on Tiny Peptide Nucleic Acid (PNA) Analogues of miRNA-34a: An in silico and Experimental Integrated Approach.

Authors:  Maria Moccia; Flavia Anna Mercurio; Emma Langella; Valerio Piacenti; Marilisa Leone; Mauro F A Adamo; Michele Saviano
Journal:  Front Chem       Date:  2020-11-23       Impact factor: 5.221

3.  Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A-U pairs in dsRNAs.

Authors:  Kiran M Patil; Desiree-Faye Kaixin Toh; Zhen Yuan; Zhenyu Meng; Zhiyu Shu; Haiping Zhang; Alan Ann Lerk Ong; Manchugondanahalli S Krishna; Lanyuan Lu; Yunpeng Lu; Gang Chen
Journal:  Nucleic Acids Res       Date:  2018-09-06       Impact factor: 16.971
  3 in total

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