Tainara Emilia Rodrigues da Silva1, Nayara Lopes Andrade1, Daiane de Oliveira Cunha2, Jacqueline Andréia Bernardes Leão-Cordeiro3, Cesar Augusto Sam Tiago Vilanova-Costa4, Antonio Márcio Teodoro Cordeiro Silva5. 1. Escola de Ciências Médicas, Biomédicas e Farmacêuticas, Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil. 2. Programa de Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil. 3. Faculdade de Enfermagem, Universidade Federal de Goiás, Goiânia, Goiás, Brazil. 4. Programa de Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil; Laboratório de Biologia Tumoral, Hospital Araújo Jorge, Associação de Combate ao Câncer em Goiás, Goiânia, Goiás, Brazil. 5. Escola de Ciências Médicas, Biomédicas e Farmacêuticas, Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil; Programa de Pós-Graduação em Ciências Ambientais e Saúde, Pontifícia Universidade Católica de Goiás, Goiânia, Goiás, Brazil. Electronic address: marciocmed@gmail.com.
Abstract
OBJECTIVE: This meta-analysis aims evaluate the association of the polymorphism rs9939609 of FTO with the risk of obesity among children and adolescents, based on the assessment of four genetic models: codominant, dominant, recessive alleles model. METHODS: Case-control studies, published between the years 2011-2015, were selected from tree available databases (PubMed, Scopus and Web of Science) and were analysed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Thirteen studies were included totalling 15,613 participants, divided into 7311 cases and 8302 controls. RESULTS: The FTO rs9939609 polymorphism was significantly associated with increased risk of obesity in children and adolescents for homozygous genotypes AA and heterozygous AT (TT vs. AT+AA: OR=0.723, 95% CI 0.629 to 0.832; p<0.0001). CONCLUSION: This meta-analysis shows that the FTO rs9939609 polymorphism in the gene is a risk factor for obesity in children and adolescents with the presence of the A allele, both homozygous genotype AA situation, as heterozygous AT.
OBJECTIVE: This meta-analysis aims evaluate the association of the polymorphism rs9939609 of FTO with the risk of obesity among children and adolescents, based on the assessment of four genetic models: codominant, dominant, recessive alleles model. METHODS: Case-control studies, published between the years 2011-2015, were selected from tree available databases (PubMed, Scopus and Web of Science) and were analysed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Thirteen studies were included totalling 15,613 participants, divided into 7311 cases and 8302 controls. RESULTS: The FTOrs9939609 polymorphism was significantly associated with increased risk of obesity in children and adolescents for homozygous genotypes AA and heterozygous AT (TT vs. AT+AA: OR=0.723, 95% CI 0.629 to 0.832; p<0.0001). CONCLUSION: This meta-analysis shows that the FTOrs9939609 polymorphism in the gene is a risk factor for obesity in children and adolescents with the presence of the A allele, both homozygous genotype AA situation, as heterozygous AT.
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