Literature DB >> 3010237

DNA sequence of the region in the genome of herpes simplex virus type 1 containing the exonuclease gene and neighbouring genes.

D J McGeoch, A Dolan, M C Frame.   

Abstract

We report the sequence of a 7800 base pair region of herpes simplex virus type 1 DNA, representing approximately 0.16 to 0.20 map units in the genome. This contains sequences transcribed into a leftward oriented set of five 3' coterminal mRNAs, together with two rightward transcribed flanking genes. One of the leftward genes encodes the virus's alkaline exonuclease, but the other gene products are uncharacterized. The amino acid sequence of one encoded protein suggested that it is a membrane embedded species. The DNA sequence is densely utilised, with two predicted out-of-frame overlaps of coding sequences, and probably six occurrences of promoter elements within coding sequences. Homologues of five of the genes were found for the distantly related Epstein-Barr virus, with a similar overall relative arrangement.

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Year:  1986        PMID： 3010237      PMCID： PMC339783          DOI： 10.1093/nar/14.8.3435

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  32 in total

1.  Identification of the herpes simplex virus DNA polymerase gene.

Authors:  D J Purifoy; R B Lewis; K L Powell
Journal:  Nature       Date:  1977-10-13       Impact factor: 49.962

2.  Mutant of herpes simplex virus type 2 with temperature-sensitive lesions affecting virion thermostability and DNase activity: identification of the lethal mutation and physical mapping of the nuc-lesion.

Authors:  P Chartrand; M C Timbury; J Hay; H Moss
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

3.  The deoxyribonuclease induced after infection of KB cells by herpes simplex virus type 1 or type 2. I. Purification and characterization of the enzyme.

Authors:  P J Hoffmann; Y C Cheng
Journal:  J Biol Chem       Date:  1978-05-25       Impact factor: 5.157

4.  A new DNA-exonuclease in cells infected with herpes virus: partial purification and properties of the enzyme.

Authors:  J M Morrison; H M Keir
Journal:  J Gen Virol       Date:  1968-12       Impact factor: 3.891

5.  mRNA- and DNA-directed synthesis of herpes simplex virus-coded exonuclease in Xenopus laevis oocytes.

Authors:  C M Preston; M G Cordingley
Journal:  J Virol       Date:  1982-08       Impact factor: 5.103

6.  Transcriptional control signals of a eukaryotic protein-coding gene.

Authors:  S L McKnight; R Kingsbury
Journal:  Science       Date:  1982-07-23       Impact factor: 47.728

7.  Alkaline deoxyribonuclease induced by herpes simplex virus type 1: composition and properties of the purified enzyme.

Authors:  M Strobel-Fidler; B Francke
Journal:  Virology       Date:  1980-06       Impact factor: 3.616

8.  Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion.

Authors:  S Lemaster; B Roizman
Journal:  J Virol       Date:  1980-09       Impact factor: 5.103

9.  Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2.

Authors:  E D Kieff; S L Bachenheimer; B Roizman
Journal:  J Virol       Date:  1971-08       Impact factor: 5.103

10.  Ribonucleotide reductase activity of synchronized KB cells infected with herpes simplex virus.

Authors:  G H Cohen
Journal:  J Virol       Date:  1972-03       Impact factor: 5.103
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  26 in total

1.  Herpesviruses encode an unusual protein-serine/threonine kinase which is nonessential for growth in cultured cells.

Authors:  N de Wind; J Domen; A Berns
Journal:  J Virol       Date:  1992-09       Impact factor: 5.103

2.  Conservation of gene organization in the lymphotropic herpesviruses herpesvirus Saimiri and Epstein-Barr virus.

Authors:  U A Gompels; M A Craxton; R W Honess
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

3.  Purification and characterization of herpes simplex virus type 1 alkaline exonuclease expressed in Escherichia coli.

Authors:  J C Bronstein; P C Weber
Journal:  J Virol       Date:  1996-03       Impact factor: 5.103

4.  Identification and characterization of a human cytomegalovirus gene coding for a membrane protein that is conserved among human herpesviruses.

Authors:  R Lehner; H Meyer; M Mach
Journal:  J Virol       Date:  1989-09       Impact factor: 5.103

5.  Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus.

Authors:  R F Smith; T F Smith
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

6.  Identification of an Epstein-Barr virus-specific desoxyribonuclease gene using complementary DNA.

Authors:  C X Zhang; G Decaussin; M de Turenne Tessier; J Daillie; T Ooka
Journal:  Nucleic Acids Res       Date:  1987-03-25       Impact factor: 16.971

7.  Structures of herpes simplex virus type 1 genes required for replication of virus DNA.

Authors:  D J McGeoch; M A Dalrymple; A Dolan; D McNab; L J Perry; P Taylor; M D Challberg
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

8.  Isolation and characterization of herpes simplex virus type 1 host range mutants defective in viral DNA synthesis.

Authors:  E P Carmichael; M J Kosovsky; S K Weller
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

9.  The UL12.5 gene product of herpes simplex virus type 1 exhibits nuclease and strand exchange activities but does not localize to the nucleus.

Authors:  Nina Bacher Reuven; Susumu Antoku; Sandra K Weller
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

10.  Antibody reactivity to an Epstein-Barr virus BERF4-encoded epitope occurring also in Asp-57 region of HLA-DQ8 beta chain. Childhood Diabetes in Finland Study Group.

Authors:  P Parkkonen; H Hyöty; J Ilonen; H Reijonen; S Ylä-Herttuala; P Leinikki
Journal:  Clin Exp Immunol       Date:  1994-02       Impact factor: 4.330
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