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Literature DB >> 301012

Protease and antiprotease levels in blood of arthritic rats.

Abstract

Protease, antiprotease, and acid phosphatase blood levels of adjuvant arthritic rats were determined. The protease levels appear to vary inversely with the antiprotease levels. Changes in the protease levels correspond closely to changes in the acid phosphatase levels. Thus it is likely that the lysosomes contribute to the proteases present in the blood. Administered cortisol appears to raise blood antiprotease levels in both normal and arthritic rats and this may reflect an anti-inflammatory action by this drug.

Entities: Chemical Species

Mesh：

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Year: 1977 PMID： 301012 PMCID： PMC1006653 DOI： 10.1136/ard.36.2.166

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

14 in total

3. Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity.

Authors: H P Schnebli
Journal: Agents Actions Date: 1979-12

4. Rabbit monoarticular arthritis as a model for intra-articular drug injections. The local action of administered cortisol and alpha-1 proteinase inhibitor.

Authors: E Pitt; D A Lewis
Journal: Agents Actions Date: 1984-12

Review 5. Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?

Authors: K D Rainsford
Journal: Agents Actions Date: 1982-10

5 in total

Protease and antiprotease levels in blood of arthritic rats.

1. Proteinase inhibitors in rheumatoid arthritis.

2. Aetiological factors in the collagen diseases. Lysosomal enzymes and the degradation of cartilage matrix.

3. The histochemical demonstration of protease by a gelatin-silver film substrate.

Review 4. Collagenase and rheumatoid arthritis.

5. Lysosomal enzyme activity in rats with adjuvant-induced arthritis.

6. Lysosome stabilization by adjuvant arthritis serum.

7. Degradation of collagen by a human granulocyte collagenolytic system.

8. The inhibition of proteinases by human alpha1-antitrypsin.

9. New methods for the determination of elastase.

10. Breakdown of cartilage proteinpolysaccharide by lysosomes.

1. Collagenase and elastase in the serum of adjuvant arthritic rats.

2. Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat.

3. Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity.

4. Rabbit monoarticular arthritis as a model for intra-articular drug injections. The local action of administered cortisol and alpha-1 proteinase inhibitor.

Review 5. Adjuvant polyarthritis in rats: is this a satisfactory model for screening anti-arthritic drugs?