Literature DB >> 6424423

Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat.

R Best, R Christian, D A Lewis.   

Abstract

Freund's complete adjuvant prepared by grinding dried, heat killed Mycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was less than 19 microns and a secondary response in the non-injected foot required particles less than 10 microns in diameter.

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Year:  1984        PMID： 6424423     DOI： 10.1007/bf01966651

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  ROLE OF LYMPH NODES IN ADJUVANT-INDUCED ARTHRITIS IN RATS.

Authors:  B B NEWBOULD
Journal:  Ann Rheum Dis       Date:  1964-09       Impact factor: 19.103

2.  EXPERIMENTAL JOINT DISEASE OBSERVATIONS ON ADJUVANT-INDUCED ARTHRITIS.

Authors:  C M PEARSON
Journal:  J Chronic Dis       Date:  1963-08

3.  A modified plethysmographic apparatus for recording volume changes in the rat paw.

Authors:  J M HARRIS; P S SPENCER
Journal:  J Pharm Pharmacol       Date:  1962-07       Impact factor: 3.765

4.  Developments in the technique of particle-size analysis by microscopical examination.

Authors:  G L FAIRS
Journal:  J R Microsc Soc       Date:  1951-09

5.  Protease and antiprotease levels in blood of arthritic rats.

Authors:  D P Parrott; D A Lewis
Journal:  Ann Rheum Dis       Date:  1977-04       Impact factor: 19.103

6.  Immunogenicity and arthritogenicity in the rat of an antigen from Mycobacterium tuberculosis wax D.

Authors:  T Koga; C M Pearson
Journal:  J Immunol       Date:  1973-08       Impact factor: 5.422

7.  Light and electron microscope studies in carragheenin, adjuvant, and tuberculin-induced arthris.

Authors:  K D Muirden; G Peace
Journal:  Ann Rheum Dis       Date:  1969-07       Impact factor: 19.103

8.  Influence of tubercle aggregate size on severity of adjuvant arthritis in the rat.

Authors:  S P Liyanage; H L Currey; B Vernon-Roberts
Journal:  Ann Rheum Dis       Date:  1975-02       Impact factor: 19.103

9.  Putrescine--a potent endogenous anti-inflammatory substance in inflammatory exudates.

Authors:  J Bird; S Mohd-Hidir; D A Lewis
Journal:  Agents Actions       Date:  1983-06
  9 in total

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