Fatemeh Shabani1, Alireza Farasat2, Majid Mahdavi1, Nematollah Gheibi3. 1. Department of Biochemistry, University of Tabriz, Tabriz, Iran. 2. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. 3. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. ngheibi@qums.ac.ir.
Abstract
BACKGROUND: Calprotectin (S100A8/S100A9), a heterodimeric EF-hand Ca2+ binding protein, are abundant in cytosol of neutrophils and are involved in inflammatory processes and several cancerous pathogens. OBJECTIVE: The purpose of the present systematic review is to evaluate the pro- and anti-tumorigenic functions of calprotectin and its relation to inflammation. MATERIALS AND METHODS: We conducted a review of studies published in the Medline (1966-2018), Scopus (2004-2018), ClinicalTrials.gov (2008-2018) and Google Scholar (2004-2018) databases, combined with studies found in the reference lists of the included studies. RESULTS: Elevated levels of S100A8/S100A9 were detected in inflammation, neoplastic tumor cells and various human cancers. Recent data have explained that many cancers arise from sites of infection, chronic irritation, and inflammation. The inflammatory microenvironment which largely includes calprotectin, has an essential role on high producing of inflammatory factors and then on neoplastic process and metastasis. CONCLUSION: Scientists have shown different outcomes in inflammation, malignancy and apoptosis whether the source of the aforementioned protein is extracellular or intracellular. These findings are offering new insights that anti-inflammatory therapeutic agents and anti-tumorigenic functions of calprotectin can lead to control cancer development.
BACKGROUND: Calprotectin (S100A8/S100A9), a heterodimeric EF-hand Ca2+ binding protein, are abundant in cytosol of neutrophils and are involved in inflammatory processes and several cancerous pathogens. OBJECTIVE: The purpose of the present systematic review is to evaluate the pro- and anti-tumorigenic functions of calprotectin and its relation to inflammation. MATERIALS AND METHODS: We conducted a review of studies published in the Medline (1966-2018), Scopus (2004-2018), ClinicalTrials.gov (2008-2018) and Google Scholar (2004-2018) databases, combined with studies found in the reference lists of the included studies. RESULTS: Elevated levels of S100A8/S100A9 were detected in inflammation, neoplastic tumor cells and various humancancers. Recent data have explained that many cancers arise from sites of infection, chronic irritation, and inflammation. The inflammatory microenvironment which largely includes calprotectin, has an essential role on high producing of inflammatory factors and then on neoplastic process and metastasis. CONCLUSION: Scientists have shown different outcomes in inflammation, malignancy and apoptosis whether the source of the aforementioned protein is extracellular or intracellular. These findings are offering new insights that anti-inflammatory therapeutic agents and anti-tumorigenic functions of calprotectin can lead to control cancer development.
Authors: Derek M Gagnon; Megan Brunjes Brophy; Sarah E J Bowman; Troy A Stich; Catherine L Drennan; R David Britt; Elizabeth M Nolan Journal: J Am Chem Soc Date: 2015-02-18 Impact factor: 15.419
Authors: Petra Tesarova; Marta Kalousova; Tomas Zima; Vladimir Tesar Journal: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Date: 2016-02-03 Impact factor: 1.245