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Literature DB >> 3008332

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.

S P Wood, I J Tickle, A M Treharne, J E Pitts, Y Mascarenhas, J Y Li, J Husain, S Cooper, T L Blundell, V J Hruby.

Abstract

Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.

Entities: Chemical Gene

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Year: 1986 PMID： 3008332 DOI： 10.1126/science.3008332

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

23 in total

Review 1. Chemistry and biology of multicomponent reactions.

Authors: Alexander Dömling; Wei Wang; Kan Wang
Journal: Chem Rev Date: 2012-03-22 Impact factor: 60.622

Review 2. Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.

Authors: Virginia M Burger; Diego O Nolasco; Collin M Stultz
Journal: J Biol Chem Date: 2016-02-05 Impact factor: 5.157

Review 3. Pharmacological versus binding analysis of receptor systems: how do they interplay? Myometrial cell receptors for oxytocin as a paradigm.

Authors: V Pliska
Journal: Experientia Date: 1991-03-15

9. Effects of conformational constraint in 2- and 8-cycloleucine analogues of oxytocin and [1-penicillamine] oxytocin examined by circular dichroism and bioassay.

Authors: I Fric; J Hlavacek; T W Rockway; W Y Chan; V J Hruby
Journal: J Protein Chem Date: 1990-02

10. Distance distributions from the tyrosyl to disulfide residues in the oxytocin and [Arg8]-vasopressin measured using frequency-domain fluorescence resonance energy transfer.

Authors: H Szmacinski; W Wiczk; M N Fishman; P S Eis; J R Lakowicz; M L Johnson
Journal: Eur Biophys J Date: 1996 Impact factor: 1.733

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.

Review 1. Chemistry and biology of multicomponent reactions.

Review 2. Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum.

Review 3. Pharmacological versus binding analysis of receptor systems: how do they interplay? Myometrial cell receptors for oxytocin as a paradigm.

4. Application of the PM6 method to modeling the solid state.

5. Dynamical search for bis-penicillamine enkephalin conformations.

6. Molecular mechanics calculations on deaminooxytocin and on deamino-arginine-vasopressin and its analogues.

Review 7. Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Review 8. Organic chemistry and biology: chemical biology through the eyes of collaboration.

9. Effects of conformational constraint in 2- and 8-cycloleucine analogues of oxytocin and [1-penicillamine] oxytocin examined by circular dichroism and bioassay.

10. Distance distributions from the tyrosyl to disulfide residues in the oxytocin and [Arg8]-vasopressin measured using frequency-domain fluorescence resonance energy transfer.