Literature DB >> 30080052

Ruthenium-Promoted C-H Activation Reactions between DNA-Conjugated Acrylamide and Aromatic Acids.

Xuan Wang1,2, Hui Sun1, Jiaxiang Liu1, Dongcheng Dai2, Mingqiang Zhang2, Hu Zhou1, Wenge Zhong2, Xiaojie Lu1.   

Abstract

The first example of DNA-compatible C-H activation reaction between DNA-conjugated acrylamides and aromatic acids has been developed. This new transformation enables aromatic acid, previously considered as monofunctional building block, to act like a bifunctional building block for the DNA encoded library synthesis. The general scope of aromatic acid was established for this new on-DNA C-H activation, which paved the way for its application in combinatorial library preparation.

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Year:  2018        PMID： 30080052     DOI： 10.1021/acs.orglett.8b01837

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

1.  A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis.

Authors:  Anokha S Ratnayake; Mark E Flanagan; Timothy L Foley; Justin D Smith; Jillian G Johnson; Justin Bellenger; Justin I Montgomery; Brian M Paegel
Journal:  ACS Comb Sci       Date:  2019-09-06       Impact factor: 3.784

2.  DNA-Compatible [3 + 2] Nitrone-Olefin Cycloaddition Suitable for DEL Syntheses.

Authors:  Christopher J Gerry; Zhenhua Yang; Michele Stasi; Stuart L Schreiber
Journal:  Org Lett       Date:  2019-02-14       Impact factor: 6.005

3.  DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules.

Authors:  Christopher J Gerry; Mathias J Wawer; Paul A Clemons; Stuart L Schreiber
Journal:  J Am Chem Soc       Date:  2019-06-25       Impact factor: 15.419

4.  Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

Authors:  James P Phelan; Simon B Lang; Jaehoon Sim; Simon Berritt; Andrew J Peat; Katelyn Billings; Lijun Fan; Gary A Molander
Journal:  J Am Chem Soc       Date:  2019-02-12       Impact factor: 15.419

5.  Ruthenium-Promoted On-DNA C-H Activation Reaction.

Authors:  Xuan Wang; Xiaojie Lu
Journal:  Methods Mol Biol       Date:  2022

6.  Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries.

Authors:  Olivier B C Monty; Pranavanand Nyshadham; Kurt M Bohren; Murugesan Palaniappan; Martin M Matzuk; Damian W Young; Nicholas Simmons
Journal:  ACS Comb Sci       Date:  2020-01-21       Impact factor: 3.784

7.  Solution-Phase DNA-Compatible Pictet-Spengler Reaction Aided by Machine Learning Building Block Filtering.

Authors:  Ke Li; Xiaohong Liu; Sixiu Liu; Yulong An; Yanfang Shen; Qingxia Sun; Xiaodong Shi; Wenji Su; Weiren Cui; Zhiqiang Duan; Letian Kuai; Hongfang Yang; Alexander L Satz; Kaixian Chen; Hualiang Jiang; Mingyue Zheng; Xuanjia Peng; Xiaojie Lu
Journal:  iScience       Date:  2020-05-07

Review 8.  DNA-encoded libraries (DELs): a review of on-DNA chemistries and their output.

Authors:  Ying Shi; Yan-Ran Wu; Jian-Qiang Yu; Wan-Nian Zhang; Chun-Lin Zhuang
Journal:  RSC Adv       Date:  2021-01-19       Impact factor: 3.361

9.  Merging C(sp3)-H activation with DNA-encoding.

Authors:  Zhoulong Fan; Shuai Zhao; Tao Liu; Peng-Xiang Shen; Zi-Ning Cui; Zhe Zhuang; Qian Shao; Jason S Chen; Anokha S Ratnayake; Mark E Flanagan; Dominik K Kölmel; David W Piotrowski; Paul Richardson; Jin-Quan Yu
Journal:  Chem Sci       Date:  2020-09-07       Impact factor: 9.825

Review 10.  Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA-Displayed Peptide Libraries.

Authors:  Paddy R A Melsen; Ryoji Yoshisada; Seino A K Jongkees
Journal:  Chembiochem       Date:  2022-02-18       Impact factor: 3.461
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