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Literature DB >> 30079419

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

Jussara Amato¹, Thushara W Madanayake, Nunzia Iaccarino, Ettore Novellino, Antonio Randazzo, Laurence H Hurley, Bruno Pagano.

Abstract

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

Entities: Chemical

Mesh：

Substances：

Year: 2018 PMID： 30079419 PMCID： PMC6234227 DOI： 10.1039/c8cc03614d

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

30 in total

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15 in total

1. Insights into telomeric G-quadruplex DNA recognition by HMGB1 protein.

Authors: Jussara Amato; Linda Cerofolini; Diego Brancaccio; Stefano Giuntini; Nunzia Iaccarino; Pasquale Zizza; Sara Iachettini; Annamaria Biroccio; Ettore Novellino; Antonio Rosato; Marco Fragai; Claudio Luchinat; Antonio Randazzo; Bruno Pagano
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Authors: Silvia Ceschi; Michele Berselli; Marta Cozzaglio; Mery Giantin; Stefano Toppo; Barbara Spolaore; Claudia Sissi
Journal: Nucleic Acids Res Date: 2022-02-22 Impact factor: 16.971

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Authors: Xi Wang; Harry M Greenblatt; Lavi S Bigman; Binhan Yu; Channing C Pletka; Yaakov Levy; Junji Iwahara
Journal: J Mol Biol Date: 2021-06-25 Impact factor: 6.151

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Journal: Nucleic Acids Res Date: 2020-06-04 Impact factor: 16.971

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Journal: Int J Mol Sci Date: 2020-10-21 Impact factor: 5.923