| Literature DB >> 30072576 |
Valur Emilsson1,2, Marjan Ilkov3, John R Lamb4, Lori L Jennings5, Vilmundur Gudnason1,6, Nancy Finkel5, Elias F Gudmundsson3, Rebecca Pitts5, Heather Hoover5, Valborg Gudmundsdottir3, Shane R Horman7, Thor Aspelund3,8, Le Shu9, Vladimir Trifonov7, Sigurdur Sigurdsson3, Andrei Manolescu10, Jun Zhu11, Örn Olafsson3, Johanna Jakobsdottir3, Scott A Lesley7, Jeremy To7, Jia Zhang7, Tamara B Harris12, Lenore J Launer12, Bin Zhang11, Gudny Eiriksdottir3, Xia Yang9, Anthony P Orth7.
Abstract
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states.Entities:
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Year: 2018 PMID： 30072576 PMCID： PMC6190714 DOI： 10.1126/science.aaq1327
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728