| Literature DB >> 25613900 |
Mathias Uhlén1, Linn Fagerberg2, Björn M Hallström3, Cecilia Lindskog4, Per Oksvold2, Adil Mardinoglu5, Åsa Sivertsson2, Caroline Kampf4, Evelina Sjöstedt6, Anna Asplund4, IngMarie Olsson4, Karolina Edlund7, Emma Lundberg2, Sanjay Navani8, Cristina Al-Khalili Szigyarto9, Jacob Odeberg2, Dijana Djureinovic4, Jenny Ottosson Takanen9, Sophia Hober9, Tove Alm2, Per-Henrik Edqvist4, Holger Berling9, Hanna Tegel9, Jan Mulder10, Johan Rockberg9, Peter Nilsson2, Jochen M Schwenk2, Marica Hamsten9, Kalle von Feilitzen2, Mattias Forsberg2, Lukas Persson2, Fredric Johansson2, Martin Zwahlen2, Gunnar von Heijne11, Jens Nielsen12, Fredrik Pontén4.
Abstract
Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray-based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.Entities:
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Year: 2015 PMID： 25613900 DOI： 10.1126/science.1260419
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728