Arunnit Boonrod1,2, Akifumi Hagiwara3,4, Masaaki Hori1, Issei Fukunaga1, Christina Andica1, Tomoko Maekawa1,5, Shigeki Aoki1. 1. Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. 2. Department of Radiology, Khon Kaen University, 123 Mittraparp Rd, Khon Kaen, 40002, Thailand. 3. Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. a-hagiwara@juntendo.ac.jp. 4. Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Honbo, Bunkyo-ku, Tokyo, 113-8655, Japan. a-hagiwara@juntendo.ac.jp. 5. Department of Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Honbo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Abstract
PURPOSE: Diffusion-weighted imaging (DWI) is a useful tool for early detection of cerebral infarction. However, recent reports have demonstrated that DWI with short effective diffusion time (∆eff) can obscure visualization of infarction. METHODS: We report three cases, including four acute-to-subacute infarctions, that demonstrated reduced visualization of the infarctions on DWI with shorter ∆eff. RESULTS: DWI was performed with different ∆eff: short and long ∆eff, using oscillating gradient spin-echo (OGSE) DWI, and intermediate ∆eff, using pulsed gradient spin-echo (PGSE) DWI. Different apparent diffusion coefficient values (due to different ∆eff) were also observed; these were considered to be the underlying causes of the under-evaluation of infarctions on DWI. CONCLUSION: The DWI with shorter ∆eff may obscure infarction. High-performance magnetic resonance imaging scanners with higher maximal gradient strength (Gmax) can perform DWI with shorter ∆eff than scanners with lower Gmax. Therefore, the appropriate ∆eff should be set for the detection of restricted diffusion.
PURPOSE: Diffusion-weighted imaging (DWI) is a useful tool for early detection of cerebral infarction. However, recent reports have demonstrated that DWI with short effective diffusion time (∆eff) can obscure visualization of infarction. METHODS: We report three cases, including four acute-to-subacute infarctions, that demonstrated reduced visualization of the infarctions on DWI with shorter ∆eff. RESULTS: DWI was performed with different ∆eff: short and long ∆eff, using oscillating gradient spin-echo (OGSE) DWI, and intermediate ∆eff, using pulsed gradient spin-echo (PGSE) DWI. Different apparent diffusion coefficient values (due to different ∆eff) were also observed; these were considered to be the underlying causes of the under-evaluation of infarctions on DWI. CONCLUSION: The DWI with shorter ∆eff may obscure infarction. High-performance magnetic resonance imaging scanners with higher maximal gradient strength (Gmax) can perform DWI with shorter ∆eff than scanners with lower Gmax. Therefore, the appropriate ∆eff should be set for the detection of restricted diffusion.
Entities:
Keywords:
Infarction; Ischemia; OGSE; Obscuration of infarction; Short diffusion time
Authors: Susie Y Huang; Aapo Nummenmaa; Thomas Witzel; Tanguy Duval; Julien Cohen-Adad; Lawrence L Wald; Jennifer A McNab Journal: Neuroimage Date: 2014-12-09 Impact factor: 6.556