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Literature DB >> 30025156

Noncanonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins.

Abstract

MicroRNAs (miRNAs) are small regulatory noncoding RNAs that are generated in the canonical RNA interference (RNAi) pathway. Drosha, DiGeorge syndrome critical region 8 (DGCR8) and Dicer are key players in miRNA biogenesis. Argonaute (Ago) proteins bind to miRNAs and are guided by them to find messenger RNA targets and carry out post-transcriptional silencing of protein-coding genes. Recently, emerging evidence suggests that RNAi factors have a range of noncanonical functions that are beyond miRNA biogenesis. These functions pertain to various biological processes, such as development, transcriptional regulation, RNA processing and maintenance of genome integrity. Here, we review recent literature reporting miRNA-independent, noncanonical functions of Drosha, DGCR8, Dicer and Ago proteins and discuss the importance of these functions.

Entities: Gene

Keywords: Argonaute proteins; Dicer; Drosha and DGCR8

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Substances：

Year: 2018 PMID： 30025156 DOI： 10.1002/1873-3468.13196

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

34 in total

Review 1. Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo.

Authors: Wen-Ting Guo; Yangming Wang
Journal: Cell Mol Life Sci Date: 2019-01-29 Impact factor: 9.261

Review 2. Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.

Authors: Akiko Hata; Giorgio Lagna
Journal: Curr Opin Hematol Date: 2019-05 Impact factor: 3.284

Review 3. Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies.

Authors: Olivier Schussler; Lara Gharibeh; Parmeseeven Mootoosamy; Nicolas Murith; Vannary Tien; Anne-Laure Rougemont; Tornike Sologashvili; Erik Suuronen; Yves Lecarpentier; Marc Ruel
Journal: Cell Mol Neurobiol Date: 2020-05-13 Impact factor: 5.046

4. Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs.

Authors: Takenori Omoto; Dilimulati Yimiti; Yohei Sanada; Minoru Toriyama; Chenyang Ding; Yuta Hayashi; Yasunari Ikuta; Tomoyuki Nakasa; Masakazu Ishikawa; Masayuki Sano; Minjung Lee; Takayuki Akimoto; Chisa Shukunami; Shigeru Miyaki; Nobuo Adachi
Journal: Front Cell Dev Biol Date: 2022-06-14

10. RNAi-Related Dicer and Argonaute Proteins Play Critical Roles for Meiocyte Formation, Chromosome-Axes Lengths and Crossover Patterning in the Fungus Sordaria macrospora.

Authors: Chloe Girard; Karine Budin; Stéphanie Boisnard; Liangran Zhang; Robert Debuchy; Denise Zickler; Eric Espagne
Journal: Front Cell Dev Biol Date: 2021-06-28

Noncanonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins.

Review 1. Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo.

Review 2. Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.

Review 3. Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies.

4. Tendon-Specific Dicer Deficient Mice Exhibit Hypoplastic Tendon Through the Downregulation of Tendon-Related Genes and MicroRNAs.

5. Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures.

Review 6. MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System.

Review 7. DICER: structure, function, and regulation.

Review 8. Conserved chromosomal functions of RNA interference.

9. Dicer- and Bulge Stem Cell-Dependent MicroRNAs During Induced Anagen Hair Follicle Development.

10. RNAi-Related Dicer and Argonaute Proteins Play Critical Roles for Meiocyte Formation, Chromosome-Axes Lengths and Crossover Patterning in the Fungus Sordaria macrospora.