Literature DB >> 3002012

Immunohistochemical localization of alpha 1-antitrypsin and alpha 1-antichymotrypsin in salivary pleomorphic adenomas.

N Murase, K Kobayashi, H Mitani, M Mori.   

Abstract

Immunohistochemical identification of alpha 1-antitrypsin (alpha 1-AT) and alpha 1-antichymotrypsin (alpha 1-ACh) in pleomorphic adenomas of salivary glands is reported in order to compare their distribution profiles with those of lysozyme and lactoferrin, already described elsewhere. Normal salivary glands indicated positive alpha 1-AT staining in ductal segments and had no alpha 1-ACh in any glandular cell. Pleomorphic adenomas displayed moderate positivity to alpha 1-AT staining in duct-like, tubular and glandular epithelia which was particularly intense in luminal cells. The limited number of tumour cells which showed duct-like structures with a single cellular layer arrangement, displayed the highest staining to alpha 1-ACh. Strongly alpha 1-AT positive tumour cells located on the inner side of luminal cavities were also markedly positive to alpha 1-ACh. Spindle shaped tumour cells existed outside tubular and ductal structures and were negative to alpha 1-AT and alpha 1-ACh. Distribution of alpha 1-AT in salivary glands was similar to that of lysozyme as is usual in ductal segments or their transformed cells, and occurrence of alpha 1-ACh localization rather resembled that of lactoferrin, with occurrence in acinar compartments and changed epithelia within acini. The biological role of a specific immunohistochemical distribution of alpha 1-AT and alpha 1-ACh in pleomorphic adenomas may be associated with a self regulating mechanism which inhibits degradation by tissue proteinases.

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Year:  1985        PMID: 3002012     DOI: 10.1007/bf00707975

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN: 0174-7398


  23 in total

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Journal:  N Engl J Med       Date:  1978-11-09       Impact factor: 91.245

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Journal:  Am J Pathol       Date:  1980-12       Impact factor: 4.307

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Authors:  C S Papadimitriou; H Stein; N X Papacharalampous
Journal:  Pathol Res Pract       Date:  1980-11       Impact factor: 3.250

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Authors:  J Travis; D Garner; J Bowen
Journal:  Biochemistry       Date:  1978-12-26       Impact factor: 3.162

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Authors:  K Aroni; C Kittas; C S Papadimitriou; N X Papacharalampous
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

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Journal:  J Histochem Cytochem       Date:  1979-03       Impact factor: 2.479

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Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1982

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Journal:  J Oral Pathol       Date:  1982

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Journal:  J Oral Pathol       Date:  1985-09

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Authors:  R A Erlandson; C Cardon-Cardo; P J Higgins
Journal:  Am J Surg Pathol       Date:  1984-11       Impact factor: 6.394

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  1 in total

1.  Multiple expression of tissue markers in mucoepidermoid carcinomas and acinic cell carcinomas of the salivary glands.

Authors:  K Hamper; W Schmitz-Wätjen; H E Mausch; J Caselitz; G Seifert
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1989
  1 in total

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