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1. Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.

Authors: R C Hubbard; F Ogushi; G A Fells; A M Cantin; S Jallat; M Courtney; R G Crystal
Journal: J Clin Invest Date: 1987-11 Impact factor: 14.808

Authors: P Philippe
Journal: Can Med Assoc J Date: 1981-03-15 Impact factor: 8.262

Authors: D Curiel; M Brantly; E Curiel; L Stier; R G Crystal
Journal: J Clin Invest Date: 1989-04 Impact factor: 14.808

Authors: F D Ledley; S L Woo
Journal: J Inherit Metab Dis Date: 1986 Impact factor: 4.982

Authors: R C Hubbard; R G Crystal
Journal: Lung Date: 1990 Impact factor: 2.584

Authors: G Massi; A Fabiano; D Ragusa; P Auconi
Journal: Hum Genet Date: 1979 Impact factor: 4.132

Authors: J C Mulley; G R Sutherland
Journal: Hum Genet Date: 1981 Impact factor: 4.132

Authors: D W Cockcroft; R K Tennent; S L Horne
Journal: Can Med Assoc J Date: 1981-03-15 Impact factor: 8.262

Authors: R van Furth; J A Kramps; A B van der Putten; R A Krom; C H Gips
Journal: Clin Exp Immunol Date: 1986-12 Impact factor: 4.330

Authors: J E Gadek; G A Fells; R L Zimmerman; S I Rennard; R G Crystal
Journal: J Clin Invest Date: 1981-10 Impact factor: 14.808