A J Søgaard1, A H Ranhoff2,3, H E Meyer2,4, T K Omsland4, W Nystad2, G S Tell2,5, K Holvik2. 1. Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. anne.johanne.sogaard@fhi.no. 2. Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway. 3. Department of Clinical Science, University of Bergen, Bergen, Norway. 4. Institute of Health and Society, University of Oslo, Oslo, Norway. 5. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Abstract
The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount. INTRODUCTION: We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003). METHODS: Socio-demographics, lifestyle, and health were self-reported and weight and height were measured in 70,568 men and 71,357 women ≥ 30 years. Information on subsequent hip fractures was retrieved from hospitals' electronic patient registries during 1994-2013. Frequency of alcohol consumption was categorized: never/seldom, moderate (≤ 2-3 times/week), or frequent (≥ 4 times/week), and amount as number of glasses per week: 0, 1-6, 7-13, 14-27, and 28+. Type of alcohol (wine vs. beer/hard liquor) was also examined. Cox's proportional hazards regression was used to estimate hazard ratios (HRs) stratified on gender and baseline age < 60 and ≥ 60 years. RESULTS: During median 15-year follow-up, 1558 men and 2511 women suffered a hip fracture. Using moderate drinkers as reference, men < 60 years drinking frequently had multivariable adjusted HR = 1.73 (CI 1.02-2.96) for hip fracture and more than 2.5 times higher risk if they consumed 14+ glasses compared to 1-6 glasses per week. In other groups of age and gender, no statistically significant increased risk was found in those consuming the highest levels of alcohol. Compared to women with moderate or frequent alcohol use, never/seldom-drinking women had the highest fracture risk. In women, use of wine was associated with lower fracture risk than other types of alcohol. CONCLUSIONS: Risk of hip fracture was highest in men < 60 years with the highest frequency and amount of alcohol consumption and in non-drinking women.
The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount. INTRODUCTION: We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003). METHODS: Socio-demographics, lifestyle, and health were self-reported and weight and height were measured in 70,568 men and 71,357 women ≥ 30 years. Information on subsequent hip fractures was retrieved from hospitals' electronic patient registries during 1994-2013. Frequency of alcohol consumption was categorized: never/seldom, moderate (≤ 2-3 times/week), or frequent (≥ 4 times/week), and amount as number of glasses per week: 0, 1-6, 7-13, 14-27, and 28+. Type of alcohol (wine vs. beer/hard liquor) was also examined. Cox's proportional hazards regression was used to estimate hazard ratios (HRs) stratified on gender and baseline age < 60 and ≥ 60 years. RESULTS: During median 15-year follow-up, 1558 men and 2511 women suffered a hip fracture. Using moderate drinkers as reference, men < 60 years drinking frequently had multivariable adjusted HR = 1.73 (CI 1.02-2.96) for hip fracture and more than 2.5 times higher risk if they consumed 14+ glasses compared to 1-6 glasses per week. In other groups of age and gender, no statistically significant increased risk was found in those consuming the highest levels of alcohol. Compared to women with moderate or frequent alcohol use, never/seldom-drinking women had the highest fracture risk. In women, use of wine was associated with lower fracture risk than other types of alcohol. CONCLUSIONS: Risk of hip fracture was highest in men < 60 years with the highest frequency and amount of alcohol consumption and in non-drinking women.
Entities:
Keywords:
Age; Alcohol consumption; Amount; Frequency; Gender; Hip fracture
Authors: A J Søgaard; K Holvik; H E Meyer; G S Tell; C G Gjesdal; N Emaus; G Grimnes; B Schei; S Forsmo; T K Omsland Journal: Osteoporos Int Date: 2016-02-22 Impact factor: 4.507
Authors: Tone K Omsland; Kristin Holvik; Haakon E Meyer; Jacqueline R Center; Nina Emaus; Grethe S Tell; Berit Schei; Aage Tverdal; Clara G Gjesdal; Guri Grimnes; Siri Forsmo; John A Eisman; Anne Johanne Søgaard Journal: Eur J Epidemiol Date: 2012-06-30 Impact factor: 8.082
Authors: C Cooper; Z A Cole; C R Holroyd; S C Earl; N C Harvey; E M Dennison; L J Melton; S R Cummings; J A Kanis Journal: Osteoporos Int Date: 2011-04-02 Impact factor: 4.507
Authors: Karina M Berg; Hillary V Kunins; Jeffrey L Jackson; Shadi Nahvi; Amina Chaudhry; Kenneth A Harris; Rubina Malik; Julia H Arnsten Journal: Am J Med Date: 2008-05 Impact factor: 4.965
Authors: Teresa T Fung; Kenneth J Mukamal; Eric B Rimm; Haakon E Meyer; Walter C Willett; Diane Feskanich Journal: Am J Clin Nutr Date: 2019-09-01 Impact factor: 7.045
Authors: Alexander J Eckert; Julia K Mader; Marcus Altmeier; Steffen Mühldorfer; Anton Gillessen; Dhayana Dallmeier; Viral N Shah; Christoph Heyer; Bettina Hartmann; Reinhard W Holl Journal: J Diabetes Complications Date: 2020-06-27 Impact factor: 2.852
Authors: Wolfgang Brozek; Hanno Ulmer; Alfonso Pompella; Gabriele Nagel; Andreas Leiherer; Oliver Preyer; Hans Concin; Emanuel Zitt Journal: Osteoporos Int Date: 2022-06-28 Impact factor: 5.071
Authors: A J Søgaard; J H Magnus; Å Bjørnerem; K Holvik; A H Ranhoff; N Emaus; H E Meyer; B H Strand Journal: Osteoporos Int Date: 2019-10-25 Impact factor: 4.507