| Literature DB >> 3000282 |
R T Johnson, D S Burke, M Elwell, C J Leake, A Nisalak, C H Hoke, W Lorsomrudee.
Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.Entities:
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Year: 1985 PMID： 3000282 DOI： 10.1002/ana.410180510
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422