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Literature DB >> 22592957

The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system.

David C Clark¹, Aaron C Brault, Elizabeth Hunsperger.

Abstract

Members of the genus Flavivirus are responsible for a spectrum of important neurological syndromes in humans and animals. Rodent models have been used extensively to model flavivirus neurological disease, to discover host-pathogen interactions that influence disease outcome, and as surrogates to determine the efficacy and safety of vaccines and therapeutics. In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models.

Entities: Disease Species

Mesh：

Year: 2012 PMID： 22592957 PMCID： PMC4581843 DOI： 10.1007/s00705-012-1337-4

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

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