| Literature DB >> 16966222 |
Ellen Gelpi1, Matthias Preusser, Ute Laggner, Ferenc Garzuly, Heidemarie Holzmann, Franz Xaver Heinz, Herbert Budka.
Abstract
In Central European tick-borne encephalitis (TBE) mechanisms of tissue destruction are poorly understood. To evaluate the contribution of immunological mechanisms to tissue injury, the authors immunohistochemically analyzed paraffin-embedded autoptic brain tissue of 26 human TBE cases. In the parenchymal compartment, there was a predominance of macrophages/microglia and cytotoxic T cells. In addition, it was found that granzyme B-expressing lymphocytes were in close contact with TBE-expressing neurons up-regulating caspase-3. These findings indicate that cellular and humoral pathways of the immune system, especially granzyme B-releasing cytotoxic T cells and macrophages/microglia, mainly contribute to tissue destruction in TBE.Entities:
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Year: 2006 PMID： 16966222 DOI： 10.1080/13550280600848746
Source DB: PubMed Journal: J Neurovirol ISSN： 1355-0284 Impact factor: 2.643