Literature DB >> 30001119

Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria.

Kenichi Matsuda1,2, Takeo Tomita1,3, Kazuo Shin-Ya1,4, Toshiyuki Wakimoto2, Tomohisa Kuzuyama1,3, Makoto Nishiyama1,3.   

Abstract

Recent studies described several different routes that facilitate nitrogen-nitrogen bond formation in natural product biosynthesis. We report herein the identification of unprecedented machinery for hydrazine formation involved in the biosynthesis of s56-p1, a dipeptide natural product with a unique hydrazone unit. The gene cassette comprising this machinery is widespread across several bacterial phyla, highlighting the overlooked potential of bacteria to synthesize hydrazine.

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Year:  2018        PMID： 30001119     DOI： 10.1021/jacs.8b05354

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  19 in total

1.  Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis.

Authors:  Shao-An Wang; Yeonjin Ko; Jia Zeng; Yujie Geng; Daan Ren; Yasushi Ogasawara; Seema Irani; Yan Zhang; Hung-Wen Liu
Journal:  J Am Chem Soc       Date:  2019-04-08       Impact factor: 15.419

2.  Identifying the Biosynthetic Gene Cluster for Triacsins with an N-Hydroxytriazene Moiety.

Authors:  Frederick F Twigg; Wenlong Cai; Wei Huang; Joyce Liu; Michio Sato; Tynan J Perez; Jiaxin Geng; Moriel J Dror; Ismael Montanez; Tate L Tong; Hyunsu Lee; Wenjun Zhang
Journal:  Chembiochem       Date:  2019-03-18       Impact factor: 3.164

3.  The l-Alanosine Gene Cluster Encodes a Pathway for Diazeniumdiolate Biosynthesis.

Authors:  Tai L Ng; Monica E McCallum; Christine R Zheng; Jennifer X Wang; Kelvin J Y Wu; Emily P Balskus
Journal:  Chembiochem       Date:  2019-12-19       Impact factor: 3.164

4.  Identification of the C-Glycoside Synthases during Biosynthesis of the Pyrazole-C-Nucleosides Formycin and Pyrazofurin.

Authors:  Daan Ren; Shao-An Wang; Yeonjin Ko; Yujie Geng; Yasushi Ogasawara; Hung-Wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2019-10-07       Impact factor: 15.336

5.  Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production.

Authors:  Isaac Antwi; Sorina Chiorean; Marco J van Belkum; John C Vederas
Journal:  RSC Med Chem       Date:  2020-04-06

6.  Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds.

Authors:  Meng Zhang; Peichao Zhang; Gudan Xu; Wenting Zhou; Yaojie Gao; Rong Gong; You-Sheng Cai; Hengjiang Cong; Zixin Deng; Neil P J Price; Xiangzhao Mao; Wenqing Chen
Journal:  Appl Environ Microbiol       Date:  2020-01-07       Impact factor: 4.792

7.  The hidden enzymology of bacterial natural product biosynthesis.

Authors:  Thomas A Scott; Jörn Piel
Journal:  Nat Rev Chem       Date:  2019-06-12       Impact factor: 34.035

Review 8.  Recent advances in the biosynthesis of nucleoside antibiotics.

Authors:  Taro Shiraishi; Tomohisa Kuzuyama
Journal:  J Antibiot (Tokyo)       Date:  2019-09-25       Impact factor: 2.649

9.  Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore.

Authors:  Antonio Del Rio Flores; Frederick F Twigg; Yongle Du; Wenlong Cai; Daniel Q Aguirre; Michio Sato; Moriel J Dror; Maanasa Narayanamoorthy; Jiaxin Geng; Nicholas A Zill; Rui Zhai; Wenjun Zhang
Journal:  Nat Chem Biol       Date:  2021-11-01       Impact factor: 16.174

Review 10.  Flavin-dependent N-hydroxylating enzymes: distribution and application.

Authors:  Carolin Mügge; Thomas Heine; Alvaro Gomez Baraibar; Willem J H van Berkel; Caroline E Paul; Dirk Tischler
Journal:  Appl Microbiol Biotechnol       Date:  2020-06-05       Impact factor: 4.813
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