Literature DB >> 29993315

What Can Diabetes-Associated Genetic Variation in TCF7L2 Teach Us About the Pathogenesis of Type 2 Diabetes?

J D Adams1, Adrian Vella1.   

Abstract

Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disorder characterized by hyperglycemia occurring as a result of impaired insulin secretion and/or insulin resistance. Among the various genetic factors associated with T2DM, a common genetic variant within the transcription factor 7-like 2 locus (TCF7L2) confers the greatest genetic risk for development of the disease. However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain. Here we review the current literature pertaining to the potential mechanisms by which TCF7L2 confers risk of T2DM, using genetic variation as a probe to understand the pathogenesis of the disease.

Entities:  

Keywords:  common genetic variation; insulin action; insulin secretion; type 2 diabetes

Mesh：

Substances：

Year:  2018        PMID： 29993315      PMCID： PMC6167616          DOI： 10.1089/met.2018.0024

Source DB:  PubMed          Journal:  Metab Syndr Relat Disord        ISSN： 1540-4196            Impact factor:   1.894


  67 in total

1.  Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus.

Authors:  P Shah; A Vella; A Basu; R Basu; W F Schwenk; R A Rizza
Journal:  J Clin Endocrinol Metab       Date:  2000-11       Impact factor: 5.958

2.  Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.

Authors:  Struan F A Grant; Gudmar Thorleifsson; Inga Reynisdottir; Rafn Benediktsson; Andrei Manolescu; Jesus Sainz; Agnar Helgason; Hreinn Stefansson; Valur Emilsson; Anna Helgadottir; Unnur Styrkarsdottir; Kristinn P Magnusson; G Bragi Walters; Ebba Palsdottir; Thorbjorg Jonsdottir; Thorunn Gudmundsdottir; Arnaldur Gylfason; Jona Saemundsdottir; Robert L Wilensky; Muredach P Reilly; Daniel J Rader; Yu Bagger; Claus Christiansen; Vilmundur Gudnason; Gunnar Sigurdsson; Unnur Thorsteinsdottir; Jeffrey R Gulcher; Augustine Kong; Kari Stefansson
Journal:  Nat Genet       Date:  2006-01-15       Impact factor: 38.330

3.  Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

Authors:  Coleen M Damcott; Toni I Pollin; Laurie J Reinhart; Sandra H Ott; Haiqing Shen; Kristi D Silver; Braxton D Mitchell; Alan R Shuldiner
Journal:  Diabetes       Date:  2006-09       Impact factor: 9.461

4.  The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.

Authors:  Qianghua Xia; Alessandra Chesi; Elisabetta Manduchi; Brian T Johnston; Sumei Lu; Michelle E Leonard; Ursula W Parlin; Eric F Rappaport; Peng Huang; Andrew D Wells; Gerd A Blobel; Matthew E Johnson; Struan F A Grant
Journal:  Diabetologia       Date:  2016-08-18       Impact factor: 10.122

5.  Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.

Authors:  Zuyao Ni; Younes Anini; Xianjun Fang; Gordon Mills; Patricia L Brubaker; Tianru Jin
Journal:  J Biol Chem       Date:  2002-11-05       Impact factor: 5.157

6.  Beta-catenin is essential for pancreatic acinar but not islet development.

Authors:  L Charles Murtaugh; Anica C Law; Yuval Dor; Douglas A Melton
Journal:  Development       Date:  2005-09-28       Impact factor: 6.868

7.  The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men.

Authors:  K Pilgaard; C B Jensen; J H Schou; V Lyssenko; L Wegner; C Brøns; T Vilsbøll; T Hansen; S Madsbad; J J Holst; A Vølund; P Poulsen; L Groop; O Pedersen; A A Vaag
Journal:  Diabetologia       Date:  2009-03-14       Impact factor: 10.122

8.  Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2.

Authors:  Inga Reynisdottir; Gudmar Thorleifsson; Rafn Benediktsson; Gunnar Sigurdsson; Valur Emilsson; Anna Sigurlin Einarsdottir; Eyrun Edda Hjorleifsdottir; Gudbjorg Th Orlygsdottir; Gudrun Thora Bjornsdottir; Jona Saemundsdottir; Skarphedinn Halldorsson; Soffia Hrafnkelsdottir; Steinunn Bjorg Sigurjonsdottir; Svana Steinsdottir; Mitchell Martin; Jarema P Kochan; Brian K Rhees; Struan F A Grant; Michael L Frigge; Augustine Kong; Vilmundur Gudnason; Kari Stefansson; Jeffrey R Gulcher
Journal:  Am J Hum Genet       Date:  2003-07-08       Impact factor: 11.025

9.  Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4.

Authors:  V Korinek; N Barker; P Moerer; E van Donselaar; G Huls; P J Peters; H Clevers
Journal:  Nat Genet       Date:  1998-08       Impact factor: 38.330

Review 10.  The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits.

Authors:  Jose C Florez; Joel Hirschhorn; David Altshuler
Journal:  Annu Rev Genomics Hum Genet       Date:  2003       Impact factor: 8.929
View more
  6 in total

1.  Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits.

Authors:  Melis A Aksit; Rhonda G Pace; Briana Vecchio-Pagán; Hua Ling; Johanna M Rommens; Pierre-Yves Boelle; Loic Guillot; Karen S Raraigh; Elizabeth Pugh; Peng Zhang; Lisa J Strug; Mitch L Drumm; Michael R Knowles; Garry R Cutting; Harriet Corvol; Scott M Blackman
Journal:  J Clin Endocrinol Metab       Date:  2020-05-01       Impact factor: 5.958

2.  Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes.

Authors:  Tanja Dujic; Tamer Bego; Maja Malenica; Zelija Velija-Asimi; Emma Ahlqvist; Leif Groop; Ewan R Pearson; Adlija Causevic; Sabina Semiz
Journal:  Bosn J Basic Med Sci       Date:  2019-11-08       Impact factor: 3.363

3.  The Effect of Diabetes-Associated Variation in TCF7L2 on Postprandial Glucose Metabolism When Glucagon and Insulin Concentrations Are Matched.

Authors:  Jon D Adams; Aoife M Egan; Marcello C Laurenti; Daniel Schembri Wismayer; Kent R Bailey; Claudio Cobelli; Chiara Dalla Man; Adrian Vella
Journal:  Metab Syndr Relat Disord       Date:  2022-04-18       Impact factor: 2.363

4.  Limitations of the fasting proinsulin to insulin ratio as a measure of β-cell health in people with and without impaired glucose tolerance.

Authors:  Aoife M Egan; Marcello C Laurenti; Maria Daniela Hurtado Andrade; Chiara Dalla Man; Claudio Cobelli; Kent R Bailey; Adrian Vella
Journal:  Eur J Clin Invest       Date:  2020-12-16       Impact factor: 5.722

5.  Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population.

Authors:  Jaroslav A Hubáček; Lenka Šedová; Věra Olišarová; Věra Adámková; Valérie Tóthová
Journal:  Mol Genet Genomic Med       Date:  2020-06-24       Impact factor: 2.183

Review 6.  Pharmacogenetics of new classes of antidiabetic drugs.

Authors:  Selma Imamovic Kadric; Aida Kulo Cesic; Tanja Dujic
Journal:  Bosn J Basic Med Sci       Date:  2021-12-01       Impact factor: 3.363
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.