| Literature DB >> 14527304 |
Jose C Florez1, Joel Hirschhorn, David Altshuler.
Abstract
Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic component. We review the division of diabetes into different subtypes based on clinical phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes, and the recent identification of several diabetes genes by large association studies. We use the lessons learned from this extensive body of evidence to illustrate general implications for the genetic analysis of complex traits.Entities:
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Year: 2003 PMID： 14527304 DOI： 10.1146/annurev.genom.4.070802.110436
Source DB: PubMed Journal: Annu Rev Genomics Hum Genet ISSN： 1527-8204 Impact factor: 8.929