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Literature DB >> 29980025

Molecular regulation of MCU: Implications in physiology and disease.

Neeharika Nemani¹, Santhanam Shanmughapriya¹, Muniswamy Madesh².

Abstract

Ca2+ flux across the inner mitochondrial membrane (IMM) regulates cellular bioenergetics, intra-cellular cytoplasmic Ca2+ signals, and various cell death pathways. Ca2+ entry into the mitochondria occurs due to the highly negative membrane potential (ΔΨm) through a selective inward rectifying MCU channel. In addition to being regulated by various mitochondrial matrix resident proteins such as MICUs, MCUb, MCUR1 and EMRE, the channel is transcriptionally regulated by upstream Ca2+ cascade, post transnational modification and by divalent cations. The mode of regulation either inhibits or enhances MCU channel activity and thus regulates mitochondrial metabolism and cell fate.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Calcium; Channel; EMRE; MCU; MCUR1; MCUb; MICU1; Magnesium; MiST; Miro1; Mitochondria; Oxidants; SLC25A23

Mesh：

Substances：

Year: 2018 PMID： 29980025 PMCID： PMC6119482 DOI： 10.1016/j.ceca.2018.06.006

Source DB: PubMed Journal: Cell Calcium ISSN： 0143-4160 Impact factor: 6.817

93 in total

Review 1. Regulation of cell death: the calcium-apoptosis link.

Authors: Sten Orrenius; Boris Zhivotovsky; Pierluigi Nicotera
Journal: Nat Rev Mol Cell Biol Date: 2003-07 Impact factor: 94.444

2. STOICHIOMETRY OF RESPIRATORY STIMULATION, ACCUMULATION OF CA++ AND PHOSPHATE, AND OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA.

Authors: C S ROSSI; A L LEHNINGER
Journal: J Biol Chem Date: 1964-11 Impact factor: 5.157

Review 3. The fateful encounter of mitochondria with calcium: how did it happen?

Authors: Ernesto Carafoli
Journal: Biochim Biophys Acta Date: 2010-04-10

4. Expression in Escherichia coli, functional characterization, and tissue distribution of isoforms A and B of the phosphate carrier from bovine mitochondria.

Authors: G Fiermonte; V Dolce; F Palmieri
Journal: J Biol Chem Date: 1998-08-28 Impact factor: 5.157

5. Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION.

Authors: Erin L Seifert; Aniko Gál; Michelle G Acoba; Qipei Li; Lauren Anderson-Pullinger; Tunde Golenár; Cynthia Moffat; Neal Sondheimer; Steven M Claypool; György Hajnóczky
Journal: J Biol Chem Date: 2016-10-25 Impact factor: 5.157

6. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

Authors: Diego De Stefani; Anna Raffaello; Enrico Teardo; Ildikò Szabò; Rosario Rizzuto
Journal: Nature Date: 2011-06-19 Impact factor: 49.962

7. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

Authors: Dipayan Chaudhuri; Daniel J Artiga; Sunday A Abiria; David E Clapham
Journal: Proc Natl Acad Sci U S A Date: 2016-03-14 Impact factor: 11.205

8. Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.

Authors: Riina M Luik; Bin Wang; Murali Prakriya; Minnie M Wu; Richard S Lewis
Journal: Nature Date: 2008-07-02 Impact factor: 49.962

9. STIM1, an essential and conserved component of store-operated Ca2+ channel function.

Authors: Jack Roos; Paul J DiGregorio; Andriy V Yeromin; Kari Ohlsen; Maria Lioudyno; Shenyuan Zhang; Olga Safrina; J Ashot Kozak; Steven L Wagner; Michael D Cahalan; Gönül Veliçelebi; Kenneth A Stauderman
Journal: J Cell Biol Date: 2005-05-02 Impact factor: 10.539

10. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Authors: Nicholas E Hoffman; Harish C Chandramoorthy; Santhanam Shanmughapriya; Xueqian Q Zhang; Sandhya Vallem; Patrick J Doonan; Karthik Malliankaraman; Shuchi Guo; Sudarsan Rajan; John W Elrod; Walter J Koch; Joseph Y Cheung; Muniswamy Madesh
Journal: Mol Biol Cell Date: 2014-01-15 Impact factor: 4.138

30 in total

1. The valosin-containing protein protects the heart against pathological Ca2+ overload by modulating Ca2+ uptake proteins.

Authors: Shaunrick Stoll; Jing Xi; Ben Ma; Christiana Leimena; Erik J Behringer; Gangjian Qin; Hongyu Qiu
Journal: Toxicol Sci Date: 2019-07-31 Impact factor: 4.849

2. Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca²⁺ uptake.

Authors: Horia Vais; Riley Payne; Usha Paudel; Carmen Li; J Kevin Foskett
Journal: Proc Natl Acad Sci U S A Date: 2020-08-14 Impact factor: 11.205

Review 3. Regulation of Mitochondrial ATP Production: Ca²⁺ Signaling and Quality Control.

Authors: Liron Boyman; Mariusz Karbowski; W Jonathan Lederer
Journal: Trends Mol Med Date: 2019-11-22 Impact factor: 11.951

4. Preventing Axonal Sodium Overload or Mitochondrial Calcium Uptake Protects Axonal Mitochondria from Oxidative Stress-Induced Alterations.

Authors: Bimala Malla; Carmen Infante-Duarte; Rebecca Ulshöfer; Helena Bros; Anja Erika Hauser; Raluca Aura Niesner; Friedemann Paul
Journal: Oxid Med Cell Longev Date: 2022-05-24 Impact factor: 7.310

Review 5. CRAC channels in secretory epithelial cell function and disease.

Authors: Haiping Liu; Ahmed Kabrah; Malini Ahuja; Shmuel Muallem
Journal: Cell Calcium Date: 2018-12-31 Impact factor: 6.817

Review 6. Ca²⁺ Signaling in Exocrine Cells.

Authors: Malini Ahuja; Woo Young Chung; Wei-Yin Lin; Beth A McNally; Shmuel Muallem
Journal: Cold Spring Harb Perspect Biol Date: 2020-05-01 Impact factor: 10.005

Review 7. Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics.

Authors: Jyoti Tanwar; Jaya Bharti Singh; Rajender K Motiani
Journal: Mitochondrion Date: 2020-12-11 Impact factor: 4.160

Molecular regulation of MCU: Implications in physiology and disease.

Review 1. Regulation of cell death: the calcium-apoptosis link.

2. STOICHIOMETRY OF RESPIRATORY STIMULATION, ACCUMULATION OF CA++ AND PHOSPHATE, AND OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA.

Review 3. The fateful encounter of mitochondria with calcium: how did it happen?

4. Expression in Escherichia coli, functional characterization, and tissue distribution of isoforms A and B of the phosphate carrier from bovine mitochondria.

5. Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION.

6. A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.

7. Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

8. Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.

9. STIM1, an essential and conserved component of store-operated Ca2+ channel function.

10. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

1. The valosin-containing protein protects the heart against pathological Ca2+ overload by modulating Ca2+ uptake proteins.

2. Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca²⁺ uptake.

Review 3. Regulation of Mitochondrial ATP Production: Ca²⁺ Signaling and Quality Control.

4. Preventing Axonal Sodium Overload or Mitochondrial Calcium Uptake Protects Axonal Mitochondria from Oxidative Stress-Induced Alterations.

Review 5. CRAC channels in secretory epithelial cell function and disease.

Review 6. Ca²⁺ Signaling in Exocrine Cells.

Review 7. Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics.

Review 8. Bcl-2-Protein Family as Modulators of IP₃ Receptors and Other Organellar Ca²⁺ Channels.

9. Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter.

Review 10. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU_cx.

Review 1. Regulation of cell death: the calcium-apoptosis link.

Review 3. The fateful encounter of mitochondria with calcium: how did it happen?

Review 3. Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control.

Review 5. CRAC channels in secretory epithelial cell function and disease.

Review 6. Ca2+ Signaling in Exocrine Cells.

Review 7. Molecular machinery regulating mitochondrial calcium levels: The nuts and bolts of mitochondrial calcium dynamics.

Review 8. Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels.

Review 10. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCUcx.

Review 3. Regulation of Mitochondrial ATP Production: Ca²⁺ Signaling and Quality Control.

Review 6. Ca²⁺ Signaling in Exocrine Cells.

Review 8. Bcl-2-Protein Family as Modulators of IP₃ Receptors and Other Organellar Ca²⁺ Channels.

Review 10. Calcium influx through the mitochondrial calcium uniporter holocomplex, MCU_cx.