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Literature DB >> 34042919

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter.

Joshua J Woods¹, Madison X Rodriguez², Chen-Wei Tsai², Ming-Feng Tsai², Justin J Wilson³.

Abstract

We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 34042919 PMCID： PMC8240128 DOI： 10.1039/d1cc01623g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.065

38 in total

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