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Literature DB >> 2997718

Sequence of the D beta 2-J beta 2 region of the human T-cell receptor beta-chain locus.

Abstract

We have sequenced the region encompassing a D beta 2 segment and the J beta 2 segments of the human T-cell antigen receptor beta-chain genes. The D beta 2 element lies about 650 base pairs upstream of a cluster of seven potentially functional J beta 2 sequences and one J beta 2 pseudogene. Examination of human beta-chain cDNA sequences which involve rearranged D beta 2 and J beta 2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J joining. Further, we present evidence for possible somatic mutation in active J beta 2 segments.

Entities: Gene Species

Mesh：

Substances：

Year: 1985 PMID： 2997718 PMCID： PMC321983 DOI： 10.1093/nar/13.18.6651

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

27 in total

1. Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes.

Authors: N R Gascoigne; Y Chien; D M Becker; J Kavaler; M M Davis
Journal: Nature Date: 1984 Aug 2-8 Impact factor: 49.962

2. Graphic methods to determine the function of nucleic acid sequences.

Authors: R Staden
Journal: Nucleic Acids Res Date: 1984-01-11 Impact factor: 16.971

3. Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Authors: F W Alt; D Baltimore
Journal: Proc Natl Acad Sci U S A Date: 1982-07 Impact factor: 11.205

Review 4. Somatic generation of antibody diversity.

Authors: S Tonegawa
Journal: Nature Date: 1983-04-14 Impact factor: 49.962

5. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes.

Authors: H Sakano; Y Kurosawa; M Weigert; S Tonegawa
Journal: Nature Date: 1981-04-16 Impact factor: 49.962

6. An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences.

Authors: R Staden
Journal: Nucleic Acids Res Date: 1982-05-11 Impact factor: 16.971

7. Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide.

Authors: M Malissen; K Minard; S Mjolsness; M Kronenberg; J Goverman; T Hunkapiller; M B Prystowsky; Y Yoshikai; F Fitch; T W Mak
Journal: Cell Date: 1984-07 Impact factor: 41.582

8. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

9. Human immunoglobulin D segments encoded in tandem multigenic families.

Authors: U Siebenlist; J V Ravetch; S Korsmeyer; T Waldmann; P Leder
Journal: Nature Date: 1981-12-17 Impact factor: 49.962

10. Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.

Authors: Y Kurosawa; S Tonegawa
Journal: J Exp Med Date: 1982-01-01 Impact factor: 14.307

12 in total

1. A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the beta-chain gene of the human T-cell receptor.

Authors: K Ikuta; T Ogura; A Shimizu; T Honjo
Journal: Nucleic Acids Res Date: 1986-06-25 Impact factor: 16.971

2. Abnormal recombination products result from aberrant DNA rearrangement of the human T-cell antigen receptor beta-chain gene.

Authors: A D Duby; J G Seidman
Journal: Proc Natl Acad Sci U S A Date: 1986-07 Impact factor: 11.205

3. Diversity and structure of human T-cell receptor beta-chain variable region genes.

Authors: P Concannon; L A Pickering; P Kung; L Hood
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

4. Modification of T cell receptor beta chain gene: the J2 region but not the J1 region of the T cell receptor beta chain gene is hypomethylated in human B cells and monocytes.

Authors: S Sakamoto; H A Young
Journal: Nucleic Acids Res Date: 1988-03-25 Impact factor: 16.971

5. Conservation of sequence in recombination signal sequence spacers.

Authors: D A Ramsden; K Baetz; G E Wu
Journal: Nucleic Acids Res Date: 1994-05-25 Impact factor: 16.971

6. Genomic sequence and organization of rabbit Tcrb constant region genes.

Authors: N Harindranath; E Lamoyi; R G Mage
Journal: Immunogenetics Date: 1989 Impact factor: 2.846

7. Chicken T-cell receptor beta-chain diversity: an evolutionarily conserved D beta-encoded glycine turn within the hypervariable CDR3 domain.

Authors: W T McCormack; L W Tjoelker; G Stella; C E Postema; C B Thompson
Journal: Proc Natl Acad Sci U S A Date: 1991-09-01 Impact factor: 11.205