Literature DB >> 7312051

Human immunoglobulin D segments encoded in tandem multigenic families.

U Siebenlist, J V Ravetch, S Korsmeyer, T Waldmann, P Leder.   

Abstract

A family of germ-line immunoglobulin D-region genes has been cloned and mapped at regular intervals along a 33-kilobase length of human chromosomal DNA. Each member of the family varies slightly in sequence, but precisely conserves the recombinational signals and spacing that flank each gene. This region seems to have been formed by the tandem amplification of large and still well conserved segments of genomic DNA. Further, structural comparisons of germ-line and rearranged D segments suggest that D segments may recombine with each other.

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Year:  1981        PMID： 7312051     DOI： 10.1038/294631a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  80 in total

1.  Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.

Authors:  J M Bye; C Carter; Y Cui; B D Gorick; S Songsivilai; G Winter; N C Hughes-Jones; J D Marks
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

2.  Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system.

Authors:  N C Hughes-Jones; J M Bye; D Beale; J Coadwell
Journal:  Biochem J       Date:  1990-05-15       Impact factor: 3.857

3.  Reconsidering the human immunoglobulin heavy-chain locus: 1. An evaluation of the expressed human IGHD gene repertoire.

Authors:  C E H Lee; B Gaëta; H R Malming; M E Bain; W A Sewell; A M Collins
Journal:  Immunogenetics       Date:  2006-01-10       Impact factor: 2.846

4.  Relationship of the CD5 B cell to human tonsillar lymphocytes that express autoantibody-associated cross-reactive idiotypes.

Authors:  T J Kipps; S F Duffy
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

5.  A deletion map of the human immunoglobulin heavy chain variable region.

Authors:  M A Walter; H M Dosch; D W Cox
Journal:  J Exp Med       Date:  1991-08-01       Impact factor: 14.307

6.  Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors.

Authors:  L Mantovani; R L Wilder; P Casali
Journal:  J Immunol       Date:  1993-07-01       Impact factor: 5.422

7.  Different stages of B cell differentiation in non-T acute lymphoblastic leukemia.

Authors:  R Foa; N Migone; M Saitta; M T Fierro; M C Giubellino; P Lusso; L Cordero di Montezemolo; R Miniero; F Lauria
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

8.  Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments.

Authors:  P Riboldi; G Gaidano; E W Schettino; T G Steger; D M Knowles; R Dalla-Favera; P Casali
Journal:  Blood       Date:  1994-05-15       Impact factor: 22.113

9.  Comparable profiles of the immunoglobulin heavy chain complementarity determining region (CDR)-3 in CD5+ and CD5- human cord blood B lymphocytes.

Authors:  H Kiyoi; K Naito; R Ohno; T Naoe
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397

10.  Characterization of the immunoglobulin heavy chain complementarity determining region (CDR)-III sequences from human B cell precursor acute lymphoblastic leukemia cells.

Authors:  H Kiyoi; T Naoe; K Horibe; R Ohno
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808
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