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Literature DB >> 2997140

DNA supercoiling and suppression of the leu-500 promoter mutation.

Abstract

top mutations (formerly supX) eliminate DNA topoisomerase I activity and suppress the leu-500 promoter mutation in Salmonella typhimurium (K. M. Overbye, S. K. Basu, and P. Margolin, Cold Spring Harbor Symp. Quant. Biol. 47:785-791, 1983). Sublethal doses of coumermycin which reduce intracellular levels of supercoiling activity in a top mutant eliminated suppression of the leu-500 mutation. This result provides evidence that increased DNA supercoiling suppresses the leu-500 promoter mutation in top mutants.

Entities: Chemical Species

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Year: 1985 PMID： 2997140 PMCID： PMC214348 DOI： 10.1128/jb.164.2.947-949.1985

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

30 in total

9. Topological promoter coupling in Escherichia coli: delta topA-dependent activation of the leu-500 promoter on a plasmid.

Authors: D Chen; R Bowater; D M Lilley
Journal: J Bacteriol Date: 1994-06 Impact factor: 3.490

10. Novobiocin-dependent topA deletion mutants of Escherichia coli.

Authors: G G Hammond; P J Cassidy; K M Overbye
Journal: J Bacteriol Date: 1991-09 Impact factor: 3.490

DNA supercoiling and suppression of the leu-500 promoter mutation.

1. Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase.

2. Native supercoiling of DNA: the effects of DNA gyrase and omega protein in E. coli.

Review 3. Biology of bacterial deoxyribonucleic acid topoisomerases.

4. Loss of DNA topoisomerase I activity alters many cellular functions in Salmonella typhimurium.

Review 5. Linkage map of Salmonella typhimurium, Edition VI.

6. Regulation of the genes for E. coli DNA gyrase: homeostatic control of DNA supercoiling.

Review 7. E. coli RNA polymerase interacts homologously with two different promoters.

8. Modulation of gene expression by drugs affecting deoxyribonucleic acid gyrase.

9. Involvement of DNA gyrase in replication and transcription of bacteriophage T7 DNA.

10. Nalidixic acid resistance: a second genetic character involved in DNA gyrase activity.

1. DNA supercoiling-dependent gene regulation in Chlamydia.

Review 2. DNA supercoiling and environmental regulation of gene expression in pathogenic bacteria.

3. In vivo supercoiling of plasmid and chromosomal DNA in an Escherichia coli hns mutant.

Review 4. DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression.

Review 5. DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression.

Review 6. Linkage map of Salmonella typhimurium, edition VII.

7. Effect of DNA superhelicity on transcription termination.

8. Transient and dynamic DNA supercoiling potently stimulates the leu-500 promoter in Escherichia coli.

9. Topological promoter coupling in Escherichia coli: delta topA-dependent activation of the leu-500 promoter on a plasmid.

10. Novobiocin-dependent topA deletion mutants of Escherichia coli.