Literature DB >> 211433

Promoter-specific inhibition of transcription by antibiotics which act on DNA gyrase.

C L Smith, M Kubo, F Imamoto.   

Abstract

Nalidixic acid, novobiocin and coumermycin specifically inhibit phage promoter-dependent transcription of the trp operon in phi 80 ptrp but not transcription from the authentic trp promoter. The nalidixic acid inhibition is not observed in an E. coli strain containing a nalAr mutation. These results indicate that DNA gyrase is involved in transcription.

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Year:  1978        PMID： 211433     DOI： 10.1038/275420a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  54 in total

1.  Differential sensitivity of gene expression in vitro to inhibitors of DNA gyrase.

Authors:  H L Yang; K Heller; M Gellert; G Zubay
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

2.  Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12.

Authors:  E Orr; N F Fairweather; I B Holland; R H Pritchard
Journal:  Mol Gen Genet       Date:  1979

3.  Inhibition of hydrogenase synthesis by DNA gyrase inhibitors in Bradyrhizobium japonicum.

Authors:  P D Novak; R J Maier
Journal:  J Bacteriol       Date:  1987-06       Impact factor: 3.490

4.  DNA supercoiling and suppression of the leu-500 promoter mutation.

Authors:  G J Pruss; K Drlica
Journal:  J Bacteriol       Date:  1985-11       Impact factor: 3.490

5.  Cloning the complete rIIB gene of bacteriophage T4 and some observations concerning its middle promoters.

Authors:  S Shinedling; L T Walker; L Gold
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

6.  Specific effects of nalidixic acid on mitochondrial gene expression in Saccharomyces cerevisiae.

Authors:  H R Mahler; J Johnson
Journal:  Mol Gen Genet       Date:  1979-10-02

7.  Evidence for RecA protein association with the cell membrane and for changes in the levels of major outer membrane proteins in SOS-induced Escherichia coli cells.

Authors:  N Garvey; A C St John; E M Witkin
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

8.  Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.

Authors:  Luciano Vozzolo; Belinda Loh; Paul J Gane; Maryame Tribak; Lihong Zhou; Ian Anderson; Elisabeth Nyakatura; Richard G Jenner; David Selwood; Ariberto Fassati
Journal:  J Biol Chem       Date:  2010-10-11       Impact factor: 5.157

9.  Effects of novobiocin, coumermycin A1, clorobiocin, and their analogs on Escherichia coli DNA gyrase and bacterial growth.

Authors:  D C Hooper; J S Wolfson; G L McHugh; M B Winters; M N Swartz
Journal:  Antimicrob Agents Chemother       Date:  1982-10       Impact factor: 5.191

10.  Chromosomes in living Escherichia coli cells are segregated into domains of supercoiling.

Authors:  R R Sinden; D E Pettijohn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-01       Impact factor: 11.205
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