Literature DB >> 2996322

Structure and alpha-adrenergic activity of pyrazinimidazolines.

R Kaliszan, B Damasiewicz, A Nasal, A Radwańska, H Foks, W Kuźmierkiewicz, D Pancechowska-Ksepko, K Rudnicka, K Wisterowicz, K Ośmiałowski.   

Abstract

The effects of newly synthetized pyrazinimidazolines on the contraction of isolated rat tail artery and on the chronotropic action of rat atria as well as the effects on blood pressure in anaesthetized rats were determined. The structure-activity relationships were studied, including standard imidazoline drugs. Starting from practically inactive derivatives the step-by-step structural modifications have been made resulting in markedly active chemical congeners, which were designed, synthetized and tested pharmacologically.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2996322     DOI： 10.1007/bf01982885

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  12 in total

1.  Calculation of hydrophobic constant (log P) from pi and f constants.

Authors:  A Leo; P Y Jow; C Silipo; C Hansch
Journal:  J Med Chem       Date:  1975-09       Impact factor: 7.446

2.  A perfused tail artery preparation from the rat.

Authors:  T E Nicholas
Journal:  J Pharm Pharmacol       Date:  1969-12       Impact factor: 3.765

3.  Receptor interactions of imidazolines. XI. Alpha-adrenergic and antihypertensive effects of clonidine and its methylene-bridged analog, St 1913.

Authors:  R R Ruffolo; E L Yaden; J E Waddell; J S Ward
Journal:  Pharmacology       Date:  1982       Impact factor: 2.547

4.  alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

Authors:  N A Flavahan; J C McGrath
Journal:  Br J Pharmacol       Date:  1981-07       Impact factor: 8.739

5.  Comparison of crystallographic and quantum mechanical analysis with biological data on clonidine and some related analogues.

Authors:  A Carpy; J M Leger; G Leclerc; N Decker; B Rouot; C G Wermuth
Journal:  Mol Pharmacol       Date:  1982-03       Impact factor: 4.436

Review 6.  Chromatography in studies of quantitative structure-activity relationships.

Authors:  R Kaliszan
Journal:  J Chromatogr       Date:  1981-05-01

7.  Presynaptic activity of the imidazolidine derivative ST 587, a highly selective alpha 1-adrenoceptor agonist.

Authors:  W Kobinger; L Pichler
Journal:  Eur J Pharmacol       Date:  1982-08-27       Impact factor: 4.432

8.  Studies on some para-substituted clonidine derivatives that exhibit an alpha-adrenoceptor stimulant activity.

Authors:  G Leclerc; B Rouot; J Schwartz; J Velly; C G Wermuth
Journal:  Br J Pharmacol       Date:  1980       Impact factor: 8.739

9.  Hypotensive and alpha-adrenergic activities of 2-(2,3,6-trichlorophenylimino) and 2-(2,3-dichloro-6-methylphenylimino) imidazolidine, two potent derivatives of clonidine.

Authors:  A de Jonge; P B Timmermans; P A van Zwieten
Journal:  Br J Pharmacol       Date:  1983-03       Impact factor: 8.739

10.  Chemistry of lofexidine.

Authors:  H Betzing; J Biedermann
Journal:  Arzneimittelforschung       Date:  1982
View more
  1 in total

1.  Antiaggregatory activity of imidazoline drugs and chemicals as a function of their structure.

Authors:  J Petrusewicz; R Kaliszan
Journal:  Agents Actions       Date:  1988-06
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.