Literature DB >> 7026584

Chromatography in studies of quantitative structure-activity relationships.

R Kaliszan.   

Abstract

The rational bases, experimental techniques and conditions required for the chromatographic determination of the structural data of importance for studies on quantitative relationships between chemical structure and biological activity of drugs (QSAR) are reviewed. Practical applications of the information gathered from various chromatographic modes in correlation with bioactivity data are discussed.

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Year:  1981        PMID： 7026584     DOI： 10.1016/s0021-9673(00)98504-2

Source DB:  PubMed          Journal:  J Chromatogr


  6 in total

1.  Analgesic activity of new pyrazine CH and NH acids and their hydrophobic and electron donating properties.

Authors:  R Kaliszan; B Pilarski; K Ośmiałowski; H Strzałkowska-Grad; E Hać
Journal:  Pharm Weekbl Sci       Date:  1985-08-23

2.  Gastric mucosal toxicity of duodenal juice constituents in the rat. Acute studies using ex vivo rat gastric chamber model.

Authors:  D Armstrong; E R Rytina; G M Murphy; R H Dowling
Journal:  Dig Dis Sci       Date:  1994-02       Impact factor: 3.199

3.  Peptide separation by reversed-phase high-performance liquid chromatography.

Authors:  T Imoto; H Yamada
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

4.  Structure and alpha-adrenergic activity of pyrazinimidazolines.

Authors:  R Kaliszan; B Damasiewicz; A Nasal; A Radwańska; H Foks; W Kuźmierkiewicz; D Pancechowska-Ksepko; K Rudnicka; K Wisterowicz; K Ośmiałowski
Journal:  Agents Actions       Date:  1985-07

5.  Development and validation of quantitative structure-activity relationship models for compounds acting on serotoninergic receptors.

Authors:  Grażyna Zydek; Elżbieta Brzezińska
Journal:  ScientificWorldJournal       Date:  2012-04-24

Review 6.  Partitioning and lipophilicity in quantitative structure-activity relationships.

Authors:  J C Dearden
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031
  6 in total

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