Literature DB >> 6265015

alpha 1-adrenoceptors can mediate chronotropic responses in the rat heart.

N A Flavahan, J C McGrath.   

Abstract

In the pithed rat, amidephrine a "selective" alpha 1-adrenoceptor agonist, evokes a positive chronotropic response. This response can be antagonized by prazosin but not by propranolol or by rauwolscine. Similarly, part of the chronotropic response to cardioaccelerator nerve stimulation is resistant to blockade by propranolol but is sensitive to prazosin or WB4101. We conclude that alpha 1-adrenoceptors can mediate a chronotropic response in the rat heart either to exogenous agonists or to the endogenous neurotransmitter noradrenaline.

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Year:  1981        PMID： 6265015      PMCID： PMC2071683          DOI： 10.1111/j.1476-5381.1981.tb16791.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  On the presence and distribution of alpha-adrenoceptors in the heart of various mammalian species.

Authors:  J Wagner; O E Brodde
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-05       Impact factor: 3.000

2.  Blockade by WB 4101 of alpha-adrenoceptors in the rat vas deferens and guinea-pig taenia caeci.

Authors:  M Butler; D H Jenkinson
Journal:  Eur J Pharmacol       Date:  1978-12-01       Impact factor: 4.432

3.  Effects of isomers of the alpha-agonist amidephrine on arterial and tracheal muscle in vitro.

Authors:  A B Buchthal; D H Jenkinson
Journal:  Eur J Pharmacol       Date:  1970-05       Impact factor: 4.432

4.  A positive inotropic effect of phenylephrine mediated through alpha adrenergic receptors.

Authors:  W C Govier
Journal:  Life Sci       Date:  1967-07-01       Impact factor: 5.037

5.  Evidence for the existence of alpha adrenergic receptor in isolated rat atria.

Authors:  M Nakashima; Y Hagino
Journal:  Jpn J Pharmacol       Date:  1972-04

6.  Effect of hypothyroid status on myocardial responses to sympathomimetic drugs.

Authors:  M Nakashima; K Maeda; A Sekiya; Y Hagino
Journal:  Jpn J Pharmacol       Date:  1971-12

7.  Interactions of sympathomimetic drugs, propranolol and phentolamine, on atrial refractory period and contractility.

Authors:  B G Benfey; D R Varma
Journal:  Br J Pharmacol Chemother       Date:  1967-08

8.  An analysis of some factors influencing alpha-adrenoceptor feed-back at the sympathetic junction in the rat heart.

Authors:  J R Docherty; J C McGrath
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

9.  A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat.

Authors:  J S Gillespie; A Maclaren; D Pollock
Journal:  Br J Pharmacol       Date:  1970-10       Impact factor: 8.739

10.  Effects of isoprenaline and phenylephrine on energy-rich phosphate compounds and glucose-6-phosphate in smooth and cardiac muscle.

Authors:  A H Weston
Journal:  Br J Pharmacol       Date:  1971-11       Impact factor: 8.739
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  15 in total

1.  Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.

Authors:  D Fedida; A P Braun; W R Giles
Journal:  J Physiol       Date:  1991-09       Impact factor: 5.182

2.  Alpha-adrenoceptor-mediated chronotropic response: influence of temperature and basal spontaneous rate.

Authors:  M C Camilion de Hurtado; O A Gende
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-03       Impact factor: 3.000

3.  Influence of vagal cooling on cardiac output in normal and beta-blocked exercising dogs.

Authors:  P G Versteeg; P Borgdorff
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1986

4.  The use of neurally released agonist in the measurement of antagonism at alpha-adrenoceptors.

Authors:  A M French; N C Scott
Journal:  Br J Pharmacol       Date:  1983-12       Impact factor: 8.739

5.  alpha 1-adrenoceptor activation can increase heart rate directly or decrease it indirectly through parasympathetic activation.

Authors:  N A Flavahan; J C McGrath
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

6.  Alpha 1-adrenoceptors in the conduction system of rat hearts.

Authors:  K Saito; T Suetsugu; Y Oku; A Kuroda; H Tanaka
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739

7.  Do both adrenaline and noradrenaline stimulate cardiac alpha-adrenoceptors to induce positive inotropy of rat atria?

Authors:  K L Williamson; K J Broadley
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

8.  External Ca-independent release of norepinephrine by sympathomimetics and its role in negative feedback modulation.

Authors:  E S Vizi; G T Somogyi; L G Harsing; I Zimanyi
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

9.  Contribution of both alpha- and beta-adrenoceptors to the inotropic effects of catecholamines in the rabbit heart.

Authors:  U Jahnel; B Kaufmann; M Rombusch; H Nawrath
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-12       Impact factor: 3.000

Review 10.  Pharmacology of combined alpha-beta-blockade. I.

Authors:  W J Louis; J J McNeil; O H Drummer
Journal:  Drugs       Date:  1984       Impact factor: 9.546
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