Mannekomba R Diagbouga1, Sandrine Morel1,2, Philippe Bijlenga2, Brenda R Kwak1. 1. Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. 2. Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Abstract
BACKGROUND: Intracranial aneurysm (IA) is a disease of the vascular wall resulting in abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of 2%-3% in the adult population. IAs are mostly small, quiescent and asymptomatic; yet, upon rupture, severe brain damage or even death is frequently encountered. In addition to clinical factors, hemodynamic forces, mainly wall shear stress (WSS), have been associated with the initiation of IAs and possibly with their risk of rupture. However, the mechanism by which WSS contributes to aneurysm growth and rupture is not completely understood. DESIGN: PubMed and Ovid MEDLINE databases were searched. In addition, key review articles were screened for relevant original publications. RESULTS: Current knowledge about the relation between WSS and IA has been obtained from both computational fluid dynamic studies in patients and experimental models of IA formation and growth. It is increasingly recognized that a high wall shear stress (gradient) participates to IA formation and that both low and high WSS can drive IA growth. Primary cilia (PC) play an important role as mechanosensors as patients with polycystic kidney disease, which is characterized by the absence or dysfunction of PC, have increased risk to develop IAs as well as increased risk of rupture. CONCLUSION: Wall shear stress is a key player in IA initiation and progression. It is involved in vascular wall remodelling and inflammation, processes underlying aneurysm pathophysiology.
BACKGROUND:Intracranial aneurysm (IA) is a disease of the vascular wall resulting in abnormal enlargement of the vessel lumen. It is a common pathology with a prevalence of 2%-3% in the adult population. IAs are mostly small, quiescent and asymptomatic; yet, upon rupture, severe brain damage or even death is frequently encountered. In addition to clinical factors, hemodynamic forces, mainly wall shear stress (WSS), have been associated with the initiation of IAs and possibly with their risk of rupture. However, the mechanism by which WSS contributes to aneurysm growth and rupture is not completely understood. DESIGN: PubMed and Ovid MEDLINE databases were searched. In addition, key review articles were screened for relevant original publications. RESULTS: Current knowledge about the relation between WSS and IA has been obtained from both computational fluid dynamic studies in patients and experimental models of IA formation and growth. It is increasingly recognized that a high wall shear stress (gradient) participates to IA formation and that both low and high WSS can drive IA growth. Primary cilia (PC) play an important role as mechanosensors as patients with polycystic kidney disease, which is characterized by the absence or dysfunction of PC, have increased risk to develop IAs as well as increased risk of rupture. CONCLUSION: Wall shear stress is a key player in IA initiation and progression. It is involved in vascular wall remodelling and inflammation, processes underlying aneurysm pathophysiology.
Authors: Aisen Vivas; Julia Mikhal; Gabriela M Ong; Anna Eigenbrodt; Andries D van der Meer; Rene Aquarius; Bernard J Geurts; Hieronymus D Boogaarts Journal: Brain Sci Date: 2022-05-05
Authors: Daniel C Baeriswyl; Ioanna Prionisti; Tom Peach; Grigoris Tsolkas; Kok Yean Chooi; John Vardakis; Sandrine Morel; Mannekomba R Diagbouga; Philippe Bijlenga; Simon Cuhlmann; Paul Evans; Brenda R Kwak; Yiannis Ventikos; Rob Krams Journal: Sci Rep Date: 2019-03-18 Impact factor: 4.379
Authors: Rafał Morga; Marek Moskała; Tadeusz Popiela; Marek Rajzer; Aleksander Wilk; Michał Kłosiński; Tomasz Muszyński; Mariusz Trystuła Journal: Med Sci Monit Date: 2020-03-31