| Literature DB >> 32844345 |
C L Karthika1, S Ahalya1, N Radhakrishnan2, C C Kartha3, S Sumi4.
Abstract
Endothelium of blood vessels is continuously exposed to various hemodynamic forces. Flow-mediated epigenetic plasticity regulates vascular endothelial function. Recent studies have highlighted the significant role of mechanosensing-related epigenetics in localized endothelial dysfunction and the regional susceptibility for lesions in vascular diseases. In this article, we review the epigenetic mechanisms such as DNA de/methylation, histone modifications, as well as non-coding RNAs in promoting endothelial dysfunction in major arterial and venous diseases, consequent to hemodynamic alterations. We also discuss the current challenges and future prospects for the use of mechanoepigenetic mediators as biomarkers of early stages of vascular diseases and dysregulated mechanosensing-related epigenetic regulators as therapeutic targets in various vascular diseases.Entities:
Keywords: Atherosclerosis; Endothelial cell; Epigenetics; Hemodynamics; Mechanosensor; Venous disease
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Year: 2020 PMID： 32844345 DOI： 10.1007/s11010-020-03890-9
Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396