Literature DB >> 2995762

Certain chromosomal regions in Streptomyces glaucescens tend to carry amplifications and deletions.

M Hasegawa, G Hintermann, J M Simonet, R Crameri, J Piret, R Hütter.   

Abstract

Streptomycetes are subject to a high degree of genetic instability. One manifestation of this phenomenon is the occurrence of tandemly reiterated DNA stretches within the chromosome. We describe the analysis of ten reiterated sequences observed in various ethidium bromide-treated streptomycin-sensitive and melanin-negative mutant strains of Streptomyces glaucescens. The repeated DNA units were 2.9 to 35 kb in length. No two sequences were identical. The amplified sequences occupied up to 45% of the total genomic DNA. Structural analysis of the cloned repeated DNA stretches by means of restriction enzymes and by cross hybridization revealed the presence of two chromosomal areas rich in DNA reiterations. In some cases reiterated regions were accompanied by nearby rearrangements.

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Year:  1985        PMID： 2995762     DOI： 10.1007/bf00425720

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  48 in total

1.  A freeze-squeeze method for recovering long DNA from agarose gels.

Authors:  R W Thuring; J P Sanders; P Borst
Journal:  Anal Biochem       Date:  1975-05-26       Impact factor: 3.365

Review 2.  Extrachromosomally determined antibiotic production.

Authors:  D A Hopwood
Journal:  Annu Rev Microbiol       Date:  1978       Impact factor: 15.500

3.  Genetic analysis in a melanin-producing streptomycete, Streptomyces glaucescens.

Authors:  R Baumann; R Hütter; D A Hopwood
Journal:  J Gen Microbiol       Date:  1974-04

4.  A simple method for the preparation of large quantities of pure plasmid DNA.

Authors:  G O Humphreys; G A Willshaw; E S Anderson
Journal:  Biochim Biophys Acta       Date:  1975-04-02

Review 5.  Transposable elements in prokaryotes.

Authors:  N Kleckner
Journal:  Annu Rev Genet       Date:  1981       Impact factor: 16.830

6.  Uses of recombinant DNA for analyses of Streptomyces species.

Authors:  C L Hershberger; J L Larson; S E Fishman
Journal:  Ann N Y Acad Sci       Date:  1983       Impact factor: 5.691

7.  A technique for the detection of large DNA alterations in complex genomes.

Authors:  G Hintermann; R Crameri; T Kieser; R Hütter
Journal:  Anal Biochem       Date:  1982-04       Impact factor: 3.365

8.  A 2.2-kilobase repeated DNA segment is associated with DNA amplification in Streptomyces fradiae.

Authors:  S E Fishman; P R Rosteck; C L Hershberger
Journal:  J Bacteriol       Date:  1985-01       Impact factor: 3.490

9.  Unstable genetic determinant of A-factor biosynthesis in streptomycin-producing organisms: cloning and characterization.

Authors:  S Horinouchi; Y Kumada; T Beppu
Journal:  J Bacteriol       Date:  1984-05       Impact factor: 3.490

10.  Hydroxystreptomycin production and resistance in Streptomyces glaucescens.

Authors:  H Ono; R Crameri; G Hintermann; R Hütter
Journal:  J Gen Microbiol       Date:  1983-02
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  21 in total

1.  Genetic instability and associated genome plasticity in Streptomyces ambofaciens: pulsed-field gel electrophoresis evidence for large DNA alterations in a limited genomic region.

Authors:  P Leblond; P Demuyter; J M Simonet; B Decaris
Journal:  J Bacteriol       Date:  1991-07       Impact factor: 3.490

2.  Intraplasmid recombination in Streptomyces lividans 66.

Authors:  C W Chen; J F Tsai; S E Chuang
Journal:  Mol Gen Genet       Date:  1987-08

3.  Chromosomal deletion and rearrangement in Streptomyces glaucescens.

Authors:  A Birch; A Häusler; C Rüttener; R Hütter
Journal:  J Bacteriol       Date:  1991-06       Impact factor: 3.490

4.  Genome conservation in isolates of Leptospira interrogans.

Authors:  J L Herrmann; C Baril; E Bellenger; P Perolat; G Baranton; I Saint Girons
Journal:  J Bacteriol       Date:  1991-12       Impact factor: 3.490

Review 5.  Genome rearrangement and genetic instability in Streptomyces spp.

Authors:  A Birch; A Häusler; R Hütter
Journal:  J Bacteriol       Date:  1990-08       Impact factor: 3.490

Review 6.  Streptomyces cloning: useful recombinant DNA systems and a summation of cloned genes.

Authors:  P K Tomich
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

7.  DNA amplification in Streptomyces achromogenes subsp. rubradiris is accompanied by a deletion, and the amplified sequences are conditionally stable and can be eliminated by two pathways.

Authors:  U Hornemann; C J Otto; X Y Zhang
Journal:  J Bacteriol       Date:  1989-11       Impact factor: 3.490

Review 8.  The impact of genetic engineering on the commercial production of antibiotics by Streptomyces and related bacteria.

Authors:  C R Hutchinson
Journal:  Appl Biochem Biotechnol       Date:  1987 Sep-Dec       Impact factor: 2.926

9.  Relationship of an unstable argG gene to a 5.7-kilobase amplifiable DNA sequence in Streptomyces lividans 66.

Authors:  M Betzler; P Dyson; H Schrempf
Journal:  J Bacteriol       Date:  1987-10       Impact factor: 3.490

10.  Heterogeneous genomic amplification in Streptomyces glaucescens: structure, location and junction sequence analysis.

Authors:  A Häusler; A Birch; W Krek; J Piret; R Hütter
Journal:  Mol Gen Genet       Date:  1989-06
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