Literature DB >> 2995236

Frequency and types of deletional alpha+-thalassemia in northern Sardinia.

A Di Rienzo, L Felicetti, A Novelletto, G Forteleoni, B Colombo.   

Abstract

We determined by restriction mapping the frequency of the -alpha 3.7 determinant in a random sample of 48 adults in Northern Sardinia. We found a frequency of 0.18 +/- 0.04 and demonstrated that only type I crossover as determined by Apa I digestion (Higgs et al. 1984) is present. Moreover, we showed that this haplotype is not associated with an Rsa I polymorphism 5' to the alpha 2-globin gene. These data support the hypothesis of a unique origin of this deletion in Sardinia.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2995236     DOI： 10.1007/bf00283371

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Alpha-thalassaemia in Africa: the oldest malaria protective trait?

Authors:  M Ramsay; T Jenkins
Journal:  Lancet       Date:  1984-08-18       Impact factor: 79.321

3.  Alpha thalassaemia in Papua New Guinea.

Authors:  S J Oppenheimer; D R Higgs; D J Weatherall; J Barker; R A Spark
Journal:  Lancet       Date:  1984-02-25       Impact factor: 79.321

4.  Independent recombination events between the duplicated human alpha globin genes; implications for their concerted evolution.

Authors:  D R Higgs; A V Hill; D K Bowden; D J Weatherall; J B Clegg
Journal:  Nucleic Acids Res       Date:  1984-09-25       Impact factor: 16.971

5.  Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination.

Authors:  A M Michelson; S H Orkin
Journal:  J Biol Chem       Date:  1983-12-25       Impact factor: 5.157

6.  Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.

Authors:  S H Embury; J A Miller; A M Dozy; Y W Kan; V Chan; D Todd
Journal:  J Clin Invest       Date:  1980-12       Impact factor: 14.808

7.  Alpha-thalassemia in two Mediterranean populations.

Authors:  M Pirastu; K Y Lee; A M Dozy; Y W Kan; G Stamatoyannopoulos; M G Hadjiminas; Z Zachariades; A Angius; M Furbetta; C Rosatelli; A Cao
Journal:  Blood       Date:  1982-08       Impact factor: 22.113

8.  Alpha thalassaemia in Sardinian newborns.

Authors:  R Galanello; L Maccioni; R Ruggeri; L Perseu; A Cao
Journal:  Br J Haematol       Date:  1984-10       Impact factor: 6.998
  8 in total
  7 in total

1.  Molecular characterization of beta-thalassemia mutations in Egypt.

Authors:  A Novelletto; M Hafez; G Deidda; A Di Rienzo; L Felicetti; H el-Tahan; Z el Morsi; M el-Ziny; Y al-Tonbary; A Sittien
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

2.  Frequency and molecular types of deletional alpha-thalassemia in Egypt.

Authors:  A Novelletto; M Hafez; A Di Rienzo; L Felicetti; G Deidda; Z el Morsi; Y al-Tonbary; M el-Ziny; N Abd-el-Gelil; L Terrenato
Journal:  Hum Genet       Date:  1989-02       Impact factor: 4.132

3.  Alpha-thalassemia haplotypes in the Algerian population.

Authors:  T Henni; F Morlé; B Lopez; P Colonna; J Godet
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

4.  A case of hereditary persistence of fetal hemoglobin caused by a gene not linked to the beta-globin cluster.

Authors:  G Martinez; A Novelletto; A Di Rienzo; L Felicetti; B Colombo
Journal:  Hum Genet       Date:  1989-07       Impact factor: 4.132

5.  Analysis of crossover type in the alpha -3.7 haplotype among sickle cell anemia patients from various parts of Africa.

Authors:  C Dodé; A Berth; J Rochette; R Girot; D Labie
Journal:  Hum Genet       Date:  1988-02       Impact factor: 4.132

6.  Molecular basis for HbH disease in Italy: geographical distribution of deletional and nondeletional alpha-thalassemia haplotypes.

Authors:  A Di Rienzo; A Novelletto; M C Aliquò; I Bianco; A Tagarelli; C Brancati; B Colombo; L Felicetti
Journal:  Am J Hum Genet       Date:  1986-11       Impact factor: 11.025

7.  Chromosome 4q35 haplotypes and DNA rearrangements segregating in affected subjects of 19 Italian families with facioscapulohumeral muscular dystrophy (FSHD).

Authors:  S Cacurri; G Deidda; N Piazzo; A Novelletto; I La Cesa; S Servidei; G Galluzzi; C Wijmenga; R R Frants; L Felicetti
Journal:  Hum Genet       Date:  1994-10       Impact factor: 4.132
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.