Sabrina Cruz1,2, Andrea Cardoso de Matos3,4,5, Suelem Pereira da Cruz6, Silvia Pereira3,4,7, Carlos Saboya4,7,8,9, Andréa Ramalho10,11,12. 1. School of Medicine, Federal University of Rio de Janeiro (UFRJ), Carlos Chagas avenue, 373, Edifício do Centro de Ciências da Saúde, 2° floor, room 49, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil. sabrina.cruz.ufrj@gmail.com. 2. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro, 21941-902, Brazil. sabrina.cruz.ufrj@gmail.com. 3. School of Medicine, Federal University of Rio de Janeiro (UFRJ), Carlos Chagas avenue, 373, Edifício do Centro de Ciências da Saúde, 2° floor, room 49, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, 21941-902, Brazil. 4. Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro, 21941-902, Brazil. 5. Federal University Fluminence (UFF), Niterói, Brazil. 6. Center for Research on Micronutrients (NPqM), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-902, Brazil. 7. Multidisciplinary Center for Bariatric and Metabolic Surgery, Rio de Janeiro, Brazil. 8. Federal University of São Paulo (UNIFESP), São Paulo, Brazil. 9. Brazilian Society of Bariatric and Metabolic Surgery, São Paulo, Brazil. 10. ENSP/FIOCRUZ, Rio de Janeiro, Brazil. 11. Department of Social and Applied Nutrition, Institute of Nutrition, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. 12. Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-902, Brazil.
Abstract
OBJECTIVE: To assess the influence of pre-pregnancy body mass index (BMI), total gestational weight gain (TGWG), and pre-pregnancy surgical success on the nutritional status of vitamin D, calcium, and parathyroid hormone (PTH) in the trimesters of pregnancy of women who previously underwent Roux-en-Y gastric bypass (RYGB). METHODOLOGY: This is an analytical, longitudinal, and retrospective study comprising 42 pregnant women who previously underwent RYGB. Concentrations of vitamin D3, calcium, and PTH were assessed in all trimesters. Anthropometric variables necessary for calculating TGWG, surgical success, and BMI were collected preoperatively and over the trimesters of pregnancy. RESULTS: A total of 97.1% had vitamin D3 inadequacy at some point in pregnancy. Pre-pregnancy BMI, even when classified as overweight, may have exacerbated the serum concentrations of this vitamin in the third trimester (p = 0.011), and it was significantly lower in women with normal weight and/or obesity (p = 0.039). It was evidenced that both pre-pregnancy BMI and TGWG above the recommended optimal weight can be associated with calcium homeostasis, especially early in pregnancy. It was also shown that surgical success in the pre-pregnancy period may have influenced the serum concentrations of vitamin D in the second trimester of pregnancy (p = 0.013). CONCLUSION: This study draws attention to the importance of monitoring the nutritional status of vitamin D3 and calcium in the prenatal period due to its relationship with pre-pregnancy BMI, TGWG, and surgical success.
OBJECTIVE: To assess the influence of pre-pregnancy body mass index (BMI), total gestational weight gain (TGWG), and pre-pregnancy surgical success on the nutritional status of vitamin D, calcium, and parathyroid hormone (PTH) in the trimesters of pregnancy of women who previously underwent Roux-en-Y gastric bypass (RYGB). METHODOLOGY: This is an analytical, longitudinal, and retrospective study comprising 42 pregnant women who previously underwent RYGB. Concentrations of vitamin D3, calcium, and PTH were assessed in all trimesters. Anthropometric variables necessary for calculating TGWG, surgical success, and BMI were collected preoperatively and over the trimesters of pregnancy. RESULTS: A total of 97.1% had vitamin D3 inadequacy at some point in pregnancy. Pre-pregnancy BMI, even when classified as overweight, may have exacerbated the serum concentrations of this vitamin in the third trimester (p = 0.011), and it was significantly lower in women with normal weight and/or obesity (p = 0.039). It was evidenced that both pre-pregnancy BMI and TGWG above the recommended optimal weight can be associated with calcium homeostasis, especially early in pregnancy. It was also shown that surgical success in the pre-pregnancy period may have influenced the serum concentrations of vitamin D in the second trimester of pregnancy (p = 0.013). CONCLUSION: This study draws attention to the importance of monitoring the nutritional status of vitamin D3 and calcium in the prenatal period due to its relationship with pre-pregnancy BMI, TGWG, and surgical success.
Entities:
Keywords:
Bariatric surgery; Body mass index; Calcium; Obesity; Pregnancy; Roux-en-Y gastric bypass; Vitamin D
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