Therese Karlsson1, Louise Andersson1, Aysha Hussain1, Marja Bosaeus1, Nina Jansson1, Amra Osmancevic2, Lena Hulthén3, Agneta Holmäng1, Ingrid Larsson4. 1. Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. 2. Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden. 3. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. 4. Department of Endocrinology, Diabetology and Metabolism, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: ingrid.larsson@medfak.gu.se.
Abstract
BACKGROUND: Obesity is associated with lower vitamin D concentrations than normal-weight. Pregnancy may affect vitamin D status, especially in obese subjects. AIMS: The purpose of this study was to compare vitamin D status and intake between obese and normal-weight women during pregnancy. METHODS:Twenty-five obese and 80 normal-weight women were recruited in the Western Sweden region (latitude 57°N). Blood samples and information on diet and sun exposure were collected in each trimester during pregnancy. RESULTS: During summer months, 12% of normal-weight and 50% of obese women in the first trimester had serum 25(OH)D concentrations <50 nmol/L (P < 0.01). Supplement use, body fat mass, season of blood sampling, and travelling to southern latitudes were the most important determinants of vitamin D status. Obese women had higher reported dietary vitamin D intake in early pregnancy compared with normal-weight women. Usage of supplements containing vitamin D was 61% in early pregnancy and declined thereafter. Nine percent of normal-weight and 33% of obese women (P < 0.01) reported a dietary vitamin D intake according to national recommendations in the beginning of pregnancy. CONCLUSIONS: Half of the obese women had what could be considered as suboptimal vitamin D status in early pregnancy and lower vitamin D status compared with normal-weight women despite reporting a higher dietary vitamin D intake. A majority of the women did not reach intake of vitamin D according to dietary recommendations.
RCT Entities:
BACKGROUND: Obesity is associated with lower vitamin D concentrations than normal-weight. Pregnancy may affect vitamin D status, especially in obese subjects. AIMS: The purpose of this study was to compare vitamin D status and intake between obese and normal-weight women during pregnancy. METHODS: Twenty-five obese and 80 normal-weight women were recruited in the Western Sweden region (latitude 57°N). Blood samples and information on diet and sun exposure were collected in each trimester during pregnancy. RESULTS: During summer months, 12% of normal-weight and 50% of obesewomen in the first trimester had serum 25(OH)D concentrations <50 nmol/L (P < 0.01). Supplement use, body fat mass, season of blood sampling, and travelling to southern latitudes were the most important determinants of vitamin D status. Obesewomen had higher reported dietary vitamin D intake in early pregnancy compared with normal-weight women. Usage of supplements containing vitamin D was 61% in early pregnancy and declined thereafter. Nine percent of normal-weight and 33% of obesewomen (P < 0.01) reported a dietary vitamin D intake according to national recommendations in the beginning of pregnancy. CONCLUSIONS: Half of the obesewomen had what could be considered as suboptimal vitamin D status in early pregnancy and lower vitamin D status compared with normal-weight women despite reporting a higher dietary vitamin D intake. A majority of the women did not reach intake of vitamin D according to dietary recommendations.
Authors: Teresa Monjardino; Ana Henriques; Carla Moreira; Teresa Rodrigues; Nuno Adubeiro; Luísa Nogueira; Cyrus Cooper; Ana Cristina Santos; Raquel Lucas Journal: J Bone Miner Res Date: 2018-11-06 Impact factor: 6.741
Authors: Cristina Palacios; Maria Angelica Trak-Fellermeier; Ricardo X Martinez; Lucero Lopez-Perez; Paul Lips; James A Salisi; Jessica C John; Juan Pablo Peña-Rosas Journal: Cochrane Database Syst Rev Date: 2019-10-03
Authors: H Svensson; L Wetterling; M Bosaeus; B Odén; A Odén; E Jennische; S Edén; A Holmäng; M Lönn Journal: Int J Obes (Lond) Date: 2015-11-13 Impact factor: 5.095