BACKGROUND: Abnormalities in calcium and vitamin D metabolism have been reported after bariatric surgery. The purpose of this study was to evaluate vitamin D nutritional status among morbidly obese patients before gastric bypass surgery. METHODS: We prospectively studied 279 morbidly obese patients seeking gastric bypass surgery for vitamin D nutritional status as assessed by serum 25-hydroxyvitamin D level. In addition, serum samples were analyzed for calcium, alkaline phosphatase (AP), intact parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D. RESULTS: Mean patient age was 43 +/- 9 years; 87% of the study patients were women, and 72% were white. Serum calcium and AP levels were normal in 88% and 89% of the patients, respectively. Vitamin D depletion, defined as serum 25-hydroxyvitamin D level <or= 20 ng/mL, was found in 166 patients (60%). An elevated PTH level was found in 48% of the patients. A significant inverse correlation was found between serum 25-hydroxyvitamin D level and both body mass index (r = .15; P = .012) and serum PTH level (r = .45; P < .001). Vitamin D depletion was significantly more prevalent in the African-American patients than in the white patients (91% vs 48%; P < .001). CONCLUSIONS: Before gastric bypass surgery, a majority of morbidly obese patients have vitamin D depletion and secondary hyperparathyroidism. Studies evaluating the effects of gastric bypass on vitamin D metabolism must consider preoperative vitamin D nutritional status. ((c)) 2006 American Society for Bariatric Surgery.
BACKGROUND: Abnormalities in calcium and vitamin D metabolism have been reported after bariatric surgery. The purpose of this study was to evaluate vitamin D nutritional status among morbidly obesepatients before gastric bypass surgery. METHODS: We prospectively studied 279 morbidly obesepatients seeking gastric bypass surgery for vitamin D nutritional status as assessed by serum 25-hydroxyvitamin D level. In addition, serum samples were analyzed for calcium, alkaline phosphatase (AP), intact parathyroid hormone (PTH), and 1,25-dihydroxyvitamin D. RESULTS: Mean patient age was 43 +/- 9 years; 87% of the study patients were women, and 72% were white. Serum calcium and AP levels were normal in 88% and 89% of the patients, respectively. Vitamin D depletion, defined as serum 25-hydroxyvitamin D level <or= 20 ng/mL, was found in 166 patients (60%). An elevated PTH level was found in 48% of the patients. A significant inverse correlation was found between serum 25-hydroxyvitamin D level and both body mass index (r = .15; P = .012) and serum PTH level (r = .45; P < .001). Vitamin D depletion was significantly more prevalent in the African-American patients than in the white patients (91% vs 48%; P < .001). CONCLUSIONS: Before gastric bypass surgery, a majority of morbidly obesepatients have vitamin D depletion and secondary hyperparathyroidism. Studies evaluating the effects of gastric bypass on vitamin D metabolism must consider preoperative vitamin D nutritional status. ((c)) 2006 American Society for Bariatric Surgery.
Authors: Radmila Levinson; Jon B Silverman; Jennifer G Catella; Iwona Rybak; Hina Jolin; Kellene Isom Journal: Obes Surg Date: 2013-07 Impact factor: 4.129
Authors: Lingtak-Neander Chan; Charlotte H Neilson; Elizabeth A Kirk; Tiana F Colovos; Diane R Javelli; Saurabh Khandelwal Journal: Obes Surg Date: 2015-12 Impact factor: 4.129
Authors: Judy Jin; Thomas A Stellato; Peter T Hallowell; Margaret Schuster; Kristen Graf; Scott Wilhelm Journal: J Gastrointest Surg Date: 2009-03-13 Impact factor: 3.452